The Role of Tomosyn in the Regulation of Neurotransmitter Release

doi:10.1007/978-3-031-34229-5_9

. 2023:33:233-254.

doi: 10.1007/978-3-031-34229-5_9.

The Role of Tomosyn in the Regulation of Neurotransmitter Release

Chun Hin Chow^{1

2}, Mengjia Huang^{1

2}, Shuzo Sugita^{3

4}

Affiliations

¹ Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
² Faculty of Medicine, Department of Physiology, University of Toronto, Toronto, ON, Canada.
³ Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Toronto, ON, Canada. Shuzo.Sugita@uhnresearch.ca.
⁴ Faculty of Medicine, Department of Physiology, University of Toronto, Toronto, ON, Canada. Shuzo.Sugita@uhnresearch.ca.

PMID: 37615869
DOI: 10.1007/978-3-031-34229-5_9

The Role of Tomosyn in the Regulation of Neurotransmitter Release

Chun Hin Chow et al. Adv Neurobiol. 2023.

. 2023:33:233-254.

doi: 10.1007/978-3-031-34229-5_9.

Authors

Chun Hin Chow^{1

2}, Mengjia Huang^{1

2}, Shuzo Sugita^{3

4}

Affiliations

¹ Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
² Faculty of Medicine, Department of Physiology, University of Toronto, Toronto, ON, Canada.
³ Division of Experimental & Translational Neuroscience, Krembil Brain Institute, University Health Network, Toronto, ON, Canada. Shuzo.Sugita@uhnresearch.ca.
⁴ Faculty of Medicine, Department of Physiology, University of Toronto, Toronto, ON, Canada. Shuzo.Sugita@uhnresearch.ca.

PMID: 37615869
DOI: 10.1007/978-3-031-34229-5_9

Abstract

Soluble NSF attachment protein receptor (SNARE) proteins play a central role in synaptic vesicle (SV) exocytosis. These proteins include the vesicle-associated SNARE protein (v-SNARE) synaptobrevin and the target membrane-associated SNARE proteins (t-SNAREs) syntaxin and SNAP-25. Together, these proteins drive membrane fusion between synaptic vesicles (SV) and the presynaptic plasma membrane to generate SV exocytosis. In the presynaptic active zone, various proteins may either enhance or inhibit SV exocytosis by acting on the SNAREs. Among the inhibitory proteins, tomosyn, a syntaxin-binding protein, is of particular importance because it plays a critical and evolutionarily conserved role in controlling synaptic transmission. In this chapter, we describe how tomosyn was discovered, how it interacts with SNAREs and other presynaptic regulatory proteins to regulate SV exocytosis and synaptic plasticity, and how its various domains contribute to its synaptic functions.

Keywords: Exocytosis; Munc18; SNARE proteins; Synaptic vesicles; Syntaxin; Tomosyn; UNC-18.

PubMed Disclaimer

References

1. Hata Y, Slaughter CA, Sudhof TC. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature. 1993;366:347–51. https://doi.org/10.1038/366347a0 . - DOI - PubMed
1. Pevsner J, Hsu SC, Scheller RH. n-Sec1: a neural-specific syntaxin-binding protein. Proc Natl Acad Sci U S A. 1994;91:1445–9. https://doi.org/10.1073/pnas.91.4.1445 . - DOI - PubMed - PMC
1. Garcia EP, Gatti E, Butler M, Burton J, De Camilli P. A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Proc Natl Acad Sci U S A. 1994;91:2003–7. https://doi.org/10.1073/pnas.91.6.2003 . - DOI - PubMed - PMC
1. Fujita Y, Shirataki H, Sakisaka T, Asakura T, Ohya T, Kotani H, et al. Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron. 1998;20:905–15. - DOI - PubMed
1. Riento K, Jantti J, Jansson S, Hielm S, Lehtonen E, Ehnholm C, et al. A sec1-related vesicle-transport protein that is expressed predominantly in epithelial cells. Eur J Biochem. 1996;239:638–46. https://doi.org/10.1111/j.1432-1033.1996.0638u.x . - DOI - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

[1] Hata Y, Slaughter CA, Sudhof TC. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature. 1993;366:347–51. https://doi.org/10.1038/366347a0 . - DOI - PubMed

[2] Hata Y, Slaughter CA, Sudhof TC. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature. 1993;366:347–51. https://doi.org/10.1038/366347a0 . - DOI - PubMed

[3] Pevsner J, Hsu SC, Scheller RH. n-Sec1: a neural-specific syntaxin-binding protein. Proc Natl Acad Sci U S A. 1994;91:1445–9. https://doi.org/10.1073/pnas.91.4.1445 . - DOI - PubMed - PMC

[4] Pevsner J, Hsu SC, Scheller RH. n-Sec1: a neural-specific syntaxin-binding protein. Proc Natl Acad Sci U S A. 1994;91:1445–9. https://doi.org/10.1073/pnas.91.4.1445 . - DOI - PubMed - PMC

[5] Garcia EP, Gatti E, Butler M, Burton J, De Camilli P. A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Proc Natl Acad Sci U S A. 1994;91:2003–7. https://doi.org/10.1073/pnas.91.6.2003 . - DOI - PubMed - PMC

[6] Garcia EP, Gatti E, Butler M, Burton J, De Camilli P. A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Proc Natl Acad Sci U S A. 1994;91:2003–7. https://doi.org/10.1073/pnas.91.6.2003 . - DOI - PubMed - PMC

[7] Fujita Y, Shirataki H, Sakisaka T, Asakura T, Ohya T, Kotani H, et al. Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron. 1998;20:905–15. - DOI - PubMed

[8] Fujita Y, Shirataki H, Sakisaka T, Asakura T, Ohya T, Kotani H, et al. Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron. 1998;20:905–15. - DOI - PubMed

[9] Riento K, Jantti J, Jansson S, Hielm S, Lehtonen E, Ehnholm C, et al. A sec1-related vesicle-transport protein that is expressed predominantly in epithelial cells. Eur J Biochem. 1996;239:638–46. https://doi.org/10.1111/j.1432-1033.1996.0638u.x . - DOI - PubMed

[10] Riento K, Jantti J, Jansson S, Hielm S, Lehtonen E, Ehnholm C, et al. A sec1-related vesicle-transport protein that is expressed predominantly in epithelial cells. Eur J Biochem. 1996;239:638–46. https://doi.org/10.1111/j.1432-1033.1996.0638u.x . - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

The Role of Tomosyn in the Regulation of Neurotransmitter Release

Affiliations

The Role of Tomosyn in the Regulation of Neurotransmitter Release

Authors

Affiliations

Abstract

Similar articles

References

MeSH terms

Substances

Abstract

Similar articles

References

MeSH terms

Substances

Related information