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. 2023 Oct;29(10):780-782.
doi: 10.1016/j.molmed.2023.08.003. Epub 2023 Aug 18.

Feel so bac: is Fusobacterium the suspect causing endometriosis?

Huan-Tzu Hou  1 , Ting-Chien Lin  2 , Meng-Hsing Wu  2 , Shaw-Jenq Tsai  3
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Feel so bac: is Fusobacterium the suspect causing endometriosis?

Huan-Tzu Hou et al. Trends Mol Med. 2023 Oct.

Abstract

Recent work by Muraoka and colleagues reports that the Gram-negative anaerobic bacterium Fusobacterium nucleatum is detected in the uterus of 64% of women with endometriosis. Fusobacterium infection causes macrophage infiltration, transforming growth factor-β production, and transgelin upregulation in human and mouse endometria as well as endometriotic lesion development in a mouse model of endometriosis.

Keywords: bacterium infection; endometriosis; macrophage infiltration; transforming growth factor-β; transgelin.

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Conflict of interest statement

Declaration of interests All authors declare no conflict of interest.

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