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Review
. 2024 Feb 1;102(1):9-27.
doi: 10.1139/bcb-2023-0155. Epub 2023 Aug 14.

LncRNAs: the good, the bad, and the unknown

Ganesan Arunkumar  1
Affiliations
Free article
Review

LncRNAs: the good, the bad, and the unknown

Ganesan Arunkumar. Biochem Cell Biol. .
Free article

Abstract

Long non-coding RNAs (lncRNAs) are significant contributors in maintaining genomic integrity through epigenetic regulation. LncRNAs can interact with chromatin-modifying complexes in both cis and trans pathways, drawing them to specific genomic loci and influencing gene expression via DNA methylation, histone modifications, and chromatin remodeling. They can also operate as building blocks to assemble different chromatin-modifying components, facilitating their interactions and gene regulatory functions. Deregulation of these molecules has been associated with various human diseases, including cancer, cardiovascular disease, and neurological disorders. Thus, lncRNAs are implicated as potential diagnostic indicators and therapeutic targets. This review discusses the current understanding of how lncRNAs mediate epigenetic control, genomic integrity, and their putative functions in disease pathogenesis.

Keywords: LncRNAs; epigenetics; genome organization; non-coding RNAs.

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Conflict of interest statement

The author declares there are no competing interests.

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