Oocyte development in XO foetuses of man and mouse: the possible role of heterologous X-chromosome pairing in germ cell survival
- PMID: 3757617
- DOI: 10.1007/BF00286989
Oocyte development in XO foetuses of man and mouse: the possible role of heterologous X-chromosome pairing in germ cell survival
Abstract
The pairing characteristics of the X axis in XO human and mouse oocytes were studied by the spreading technique throughout meiotic prophase. In three human XO foetuses, germ cell development was seen to be largely blocked at the preleptotene stage. In XO mice on the other hand, oocytes surviving through pachytene increasingly show the X axis making a non-homologous association with itself or with an autosome. Such associations take the form hairpins or rings when self pairing occurs or triradial structures when involvement is with an autosome. Pairing initiation in the autosomes involved is disturbed by the X axis suggesting that the heterologous pairing seen is taking place at the earliest stage of synaptonemal complex formation, namely zygotene. It is suggested, that in the XO mouse, and perhaps also in rare fertile XO humans, survival, of a population of oocytes into the adult is ensured by the ability of the X axis to pair non-homologously at meiotic prophase, thus satisfying pairing requirements.
Similar articles
-
The behavior of the X- and Y-chromosomes in the oocyte during meiotic prophase in the B6.Y(TIR)sex-reversed mouse ovary.Reproduction. 2008 Feb;135(2):241-52. doi: 10.1530/REP-07-0383. Reproduction. 2008. PMID: 18239052
-
Meiotic pairing and gametogenic failure.Symp Soc Exp Biol. 1984;38:349-62. Symp Soc Exp Biol. 1984. PMID: 6545729
-
Continuous loss of oocytes throughout meiotic prophase in the normal mouse ovary.Dev Biol. 2003 Jun 15;258(2):334-48. doi: 10.1016/s0012-1606(03)00132-5. Dev Biol. 2003. PMID: 12798292
-
Perinatal oocyte loss in XO mice and its implications for the aetiology of gonadal dysgenesis in XO women.J Reprod Fertil. 1985 Nov;75(2):633-45. doi: 10.1530/jrf.0.0750633. J Reprod Fertil. 1985. PMID: 3906118
-
The molecular control of meiotic chromosomal behavior: events in early meiotic prophase in Drosophila oocytes.Annu Rev Physiol. 2012;74:425-51. doi: 10.1146/annurev-physiol-020911-153342. Annu Rev Physiol. 2012. PMID: 22335798 Review.
Cited by
-
Function of the sex chromosomes in mammalian fertility.Cold Spring Harb Perspect Biol. 2011 Oct 1;3(10):a002675. doi: 10.1101/cshperspect.a002675. Cold Spring Harb Perspect Biol. 2011. PMID: 21730045 Free PMC article. Review.
-
Germ cell sex determination in mammals.Mol Hum Reprod. 2009 Apr;15(4):205-13. doi: 10.1093/molehr/gap008. Epub 2009 Feb 13. Mol Hum Reprod. 2009. PMID: 19218284 Free PMC article. Review.
-
Evaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.PLoS One. 2010 Dec 14;5(12):e15598. doi: 10.1371/journal.pone.0015598. PLoS One. 2010. PMID: 21179482 Free PMC article.
-
Failure of homologous synapsis and sex-specific reproduction problems.Front Genet. 2012 Jun 18;3:112. doi: 10.3389/fgene.2012.00112. eCollection 2012. Front Genet. 2012. PMID: 22719750 Free PMC article.
-
The role of sex chromosomes in mammalian germ cell differentiation: can the germ cells carrying X and Y chromosomes differentiate into fertile oocytes?Asian J Androl. 2015 May-Jun;17(3):360-6. doi: 10.4103/1008-682X.143306. Asian J Androl. 2015. PMID: 25578929 Free PMC article. Review.