Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug 6;15(15):3990.
doi: 10.3390/cancers15153990.

Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy

Devon C Freudenberger  1 , Vignesh Vudatha  1 , Luke G Wolfe  1 , Andrea N Riner  2 , Kelly M Herremans  2 , Brian K Sparkman  1 , Leopoldo J Fernandez  1 , Jose G Trevino  1
Affiliations

Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy

Devon C Freudenberger et al. Cancers (Basel). .

Abstract

Appendiceal cancer treatment may include cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We investigated whether patient race/ethnicity influences outcomes and overall survival for patients with appendiceal cancer who undergo CRS/HIPEC. We queried the National Cancer Database for adult patients with appendiceal cancer treated with CRS/HIPEC from 2006 to 2018. Patients were stratified by race/ethnicity: non-Hispanic White (NHW), non-Hispanic Black (NHB), Hispanic, and Other. Sociodemographics and outcomes were compared using descriptive statistics. Kaplan-Meier survival analysis and Log-rank tests assessed differences in overall survival (OS). Cox Multivariate Regression evaluated factors associated with OS. In total, 2532 patients were identified: 2098 (82.9%) NHW, 186 (7.3%) NHB, 127 (5.0%) Hispanic, and 121 (4.8%) Other patients. The sociodemographics were statistically different across groups. The perioperative and postoperative outcomes were similar. OS was significantly different by race/ethnicity (p = 0.0029). NHB patients compared to Hispanic patients had the shortest median OS (106.7 vs. 145.9 months, p = 0.0093). Race/ethnicity was independently associated with OS: NHB (HR: 2.117 [1.306, 3.431], p = 0.0023) and NHW (HR: 1.549 [1.007, 2.383], p = 0.0463) patients compared to Hispanic patients had worse survival rates. Racial/ethnic disparities exist for patients with appendiceal cancer undergoing CRS/HIPEC. Despite having similar tumor and treatment characteristics, OS is associated with patient race/ethnicity.

Keywords: appendiceal cancer; cancer survivorship; cytoreductive surgery (CRS); hyperthermic intraperitoneal chemotherapy (HIPEC); racial disparities.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The information presented by the authors is their own, and this material should not be interpreted as representing the viewpoint of the supporting funders/sponsors. The American College of Surgeons and the Commission on Cancer have not verified and are not responsible for the analytic of statistical methodology employed or the conclusions drawn from these data.

Figures

Figure 1
Figure 1
Overall survival by patient race/ethnicity. Median overall survival was reached by patients in the non-Hispanic White (136.3 months), non-Hispanic Black (106.7 months), and Hispanic (145.9 months) racial/ethnic groups, while patients in the Other racial/ethnic group did not reach median overall survival in this study’s timeframe (p = 0.003).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Zavala V.A., Bracci P.M., Carethers J.M., Carvajal-Carmona L., Coggins N.B., Cruz-Correa M.R., Davis M., de Smith A.J., Dutil J., Figueiredo J.C., et al. Cancer Health Disparities in Racial/Ethnic Minorities in the United States. Br. J. Cancer. 2021;124:315–332. doi: 10.1038/s41416-020-01038-6. - DOI - PMC - PubMed
    1. Sukumar S., Ravi P., Sood A., Gervais M.K., Hu J.C., Kim S.P., Menon M., Roghmann F., Sammon J.D., Sun M., et al. Racial Disparities in Operative Outcomes after Major Cancer Surgery in the United States. World J. Surg. 2015;39:634–643. doi: 10.1007/s00268-014-2863-x. - DOI - PubMed
    1. Lutfi W., Zenati M.S., Zureikat A.H., Zeh H.J., Hogg M.E. Health Disparities Impact Expected Treatment of Pancreatic Ductal Adenocarcinoma Nationally. Ann. Surg. Oncol. 2018;25:1860–1867. doi: 10.1245/s10434-018-6487-5. - DOI - PubMed
    1. Nizam W., Yeo H.L., Obeng-Gyasi S., Brock M.V., Johnston F.M. Disparities in Surgical Oncology: Management of Advanced Cancer. Ann. Surg. Oncol. 2021;28:8056–8073. doi: 10.1245/s10434-021-10275-9. - DOI - PMC - PubMed
    1. Elias D., Lefevre J.H., Chevalier J., Brouquet A., Marchal F., Classe J.M., Ferron G., Guilloit J.M., Meeus P., Goéré D., et al. Complete Cytoreductive Surgery plus Intraperitoneal Chemohyperthermia with Oxaliplatin for Peritoneal Carcinomatosis of Colorectal Origin. J. Clin. Oncol. 2009;27:681–685. doi: 10.1200/JCO.2008.19.7160. - DOI - PubMed

LinkOut - more resources