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Review
. 2023 Jul 21:13:1224138.
doi: 10.3389/fonc.2023.1224138. eCollection 2023.

A spotlight on the interplay between Wnt/β-catenin signaling and circular RNAs in hepatocellular carcinoma progression

Alireza Mafi  1   2 , Hamidreza Rismanchi  3 , Mohaddese Malek Mohammadi  3 , Neda Hedayati  4 , Seyedeh Sara Ghorbanhosseini  1 , Seyed Ali Hosseini  5 , Yasaman Gholinezhad  6 , Rohollah Mousavi Dehmordi  1   7 , Behrooz Ghezelbash  8 , Fatemeh Zarepour  9 , Seyed Pouya Taghavi  9 , Zatollah Asemi  10 , Mina Alimohammadi  11 , Hamed Mirzaei  10
Affiliations
Review

A spotlight on the interplay between Wnt/β-catenin signaling and circular RNAs in hepatocellular carcinoma progression

Alireza Mafi et al. Front Oncol. .

Abstract

Hepatocellular carcinoma (HCC) is one of the deadliest cancers due to multifocal development and distant metastasis resulting from late diagnosis. Consequently, new approaches to HCC diagnosis and treatment are required to reduce mortality rates. A large body of evidence suggests that non-coding RNAs (ncRNAs) are important in cancer initiation and progression. Cancer cells release many of these ncRNAs into the blood or urine, enabling their use as a diagnostic tool. Circular RNAs (CircRNAs) are as a members of the ncRNAs that regulate cancer cell expansion, migration, metastasis, and chemoresistance through different mechanisms such as the Wnt/β-catenin Signaling pathway. The Wnt/β-catenin pathway plays prominent roles in several biological processes including organogenesis, stem cell regeneration, and cell survival. Aberrant signaling of both pathways mentioned above could affect the progression and metastasis of many cancers, including HCC. Based on several studies investigated in the current review, circRNAs have an effect on HCC formation and progression by sponging miRNAs and RNA-binding proteins (RBPs) and regulating the Wnt/β-catenin signaling pathway. Therefore, circRNAs/miRNAs or RBPs/Wnt/β-catenin signaling pathway could be considered promising prognostic and therapeutic targets in HCC.

Keywords: Wnt signaling; circRNA; hepatocellular carcinoma; mechanism; non-coding RNA.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
A schema of canonical and non-canonical Wnt signaling pathway.
Figure 2
Figure 2
By sponging miRNAs, circRNA molecules regulate the Wnt signaling pathway for further modulation of HCC development in a positive and/or negative manner.
See this image and copyright information in PMC

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References

    1. Chang W-T, Bow Y-D, Fu P-J, Li C-Y, Wu C-Y, Chang Y-H, et al. . A marine terpenoid, heteronemin, induces both the apoptosis and ferroptosis of hepatocellular carcinoma cells and involves the ROS and MAPK pathways. Oxid Med Cell Longevity (2021) 2021:7689045. doi: 10.1155/2021/7689045 - DOI - PMC - PubMed
    1. Rossi L, Zoratto F, Papa A, Iodice F, Minozzi M, Frati L, et al. . Current approach in the treatment of hepatocellular carcinoma. World J Gastrointest Oncol (2010) 2(9):348–59. doi: 10.4251/wjgo.v2.i9.348 - DOI - PMC - PubMed
    1. Moeinabadi-Bidgoli K, Rezaee M, Rismanchi H, Mohammadi MM, Babajani A. Mesenchymal stem cell-derived antimicrobial peptides as potential anti-neoplastic agents: new insight into anticancer mechanisms of stem cells and exosomes. Front Cell Dev Biol (2022) 10:900418. doi: 10.3389/fcell.2022.900418 - DOI - PMC - PubMed
    1. Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol (2014) 740:364–78. doi: 10.1016/j.ejphar.2014.07.025 - DOI - PMC - PubMed
    1. Wang W, Huang Z, Guo B, Liu S, Xiao W, Liang J. Short- and long-term outcomes of laparoscopic hepatectomy in elderly patients with hepatocellular carcinoma. J BUON (2018) 23(4):971–8. - PubMed

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