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. 2023 Jul 31.
doi: 10.1007/s12033-023-00813-z. Online ahead of print.

Effect of Diabetic Neuropathy on Reparative Ability and Immune Response System

Emina Karahmet Sher  1 , Besim Prnjavorac  2 , Esma Karahmet Farhat  3   4 , Benjamin Palić  5 , Sabah Ansar  6 , Farooq Sher  7
Affiliations

Effect of Diabetic Neuropathy on Reparative Ability and Immune Response System

Emina Karahmet Sher et al. Mol Biotechnol. .

Abstract

The effects of diabetes can be divided into short, medium and long term and various human organ systems can be effected. The present study aimed to determine how much the duration of diabetes mellitus (DM) affect the reparative ability of the body, immune response and the development of DM complications. Interleukin 1-β (IL-1β) and Interleukin 6 (IL-6) were monitored as specific indicators of inflammatory reaction and C-reactive protein (CRP), leukocyte count (WBC) and sedimentation rate (ESR) as general markers of inflammatory reaction. Tumour necrosis factor α (TNF-α) and transforming growth factor β1 (TGF-β1) were observed as indicators of reparative ability and polyneuropathy. All interleukins were determined by ELISA and evaluated spectrophotometrically. Michigan Neuropathy Screening Instrument (MNSI) is performed for neuropathy examination. Patients with diabetes mellitus were divided into 3 groups, according to duration of diabetes mellitus. IL-6 levels correlated with clinical stage of diabetic polyneuropathy at p = 0.025 R = 0.402; with CRP at p = 0.0001, R = 0.784 as well as correlation of CRP and MNSI score (R = 0.500, p = 0.034) in a group of patients with DM lasting up to 10 years. The reparative ability of the body is reduced by physiological age and ages of DM duration. The immune response is weakened in DM additionally. The dual activity of cytokines IL-6 and TGF-β1 is present in long-duration Diabetes Mellitus.

Keywords: Cytokines; Diabetic polyneuropathy; Immune response; Long-term effects of DM; Neuroimmunology; Reparative ability.

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