Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr;62(2):1021-1039.
doi: 10.1007/s10528-023-10460-3. Epub 2023 Jul 30.

Comprehensive Characterization of Immune Cell Infiltration Characteristics and Drug Sensitivity Analysis in Inflammatory Breast Cancer Based on Bioinformatic Strategy

Zhengguang Zhang  1 , Haitao Wu  2 , Cunsi Shen  3 , Fuqiong Zhou  4
Affiliations

Comprehensive Characterization of Immune Cell Infiltration Characteristics and Drug Sensitivity Analysis in Inflammatory Breast Cancer Based on Bioinformatic Strategy

Zhengguang Zhang et al. Biochem Genet. 2024 Apr.

Abstract

Inflammatory breast cancer (IBC) is a rare and highly invasive form of breast cancer, renowned for its aggressive behavior, malignant capacity, and unfavorable prognosis. Despite considerable advancements in comprehending the underlying biology of IBC, the immune cell infiltration (ICI) profile in IBC remains inadequately elucidated. The current work endeavors to investigate the ICI characteristics of IBC and ascertain the pivotal immune cell subtypes and genes that impact its prognosis. The present study employed microarray data from the GEO database to demonstrate that IBC exhibited a lower abundance of activated mast cells (AMC) in comparison to non-inflammatory breast cancer (nIBC) or normal breast tissue (NBT). Additionally, the mRNA expression level of the gene polo-like kinase 5 (PLK5), which was correlated with AMC, was found to be lower in IBC relative to nIBC or NBT. Furthermore, this investigation provided compelling evidence indicating a potential association between a decreased mRNA expression level of PLK5 and a shorter progression-free survival in patients with breast cancer. The gene set enrichment analysis performed on PLK5 revealed that the gene expression in IBC was closely associated with diverse immune functions and pathways. Besides, a negative correlation has been established between PLK5 mRNA expression level and a majority of immune checkpoint-related genes, thereby suggesting the potential suitability of immunotherapy treatment for IBC. In summary, this study offers valuable insights into the ICI profile of IBC and identifies potential target PLK5 for improving its clinical management.

Keywords: Activated mast cells; Immune cell infiltration; Inflammatory breast cancer; Polo-like kinase 5.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Adesoye T, Lucci A (2021) Current surgical management of inflammatory breast cancer. Ann Surg Oncol 28:5461–5467. https://doi.org/10.1245/s10434-021-10522-z - DOI - PubMed
    1. Alonso-Miguel D, Fiering S, Arias-Pulido H (2022) Proactive immunotherapeutic approaches against inflammatory breast cancer may improve patient outcomes. Cells 11:2850. https://doi.org/10.3390/cells11182850 - DOI - PubMed - PMC
    1. Balema W, Liu D, Shen Y et al (2021) Inflammatory breast cancer appearance at presentation is associated with overall survival. Cancer Med 10:6261–6272. https://doi.org/10.1002/cam4.4170 - DOI - PubMed - PMC
    1. Bertucci F, Boudin L, Finetti P et al (2021) Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors. Oncoimmunology 10:1929724. https://doi.org/10.1080/2162402X.2021.1929724 - DOI - PubMed - PMC
    1. Chainitikun S, Saleem S, Lim B et al (2021) Update on systemic treatment for newly diagnosed inflammatory breast cancer. J Adv Res 29:1–12. https://doi.org/10.1016/j.jare.2020.08.014 - DOI - PubMed

MeSH terms

LinkOut - more resources