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. 2023 Jul 17;13(1):11486.
doi: 10.1038/s41598-023-37815-5.

Poststroke neutrophil count is predictive of the outcomes of large-artery atherosclerotic stroke and associated with craniocervical atherosclerosis

Yi Yang #  1 , Yue He #  1 , Yuhao Xu  1 , Wei Han  1 , Tian Zhao  2 , Yuanwei Shao  2 , Ming Yu  3
Affiliations

Poststroke neutrophil count is predictive of the outcomes of large-artery atherosclerotic stroke and associated with craniocervical atherosclerosis

Yi Yang et al. Sci Rep. .

Abstract

Elevation of the neutrophil count is detrimental to the outcome of patients with stroke. The effect of poststroke neutrophil count on the outcome of patients with large-artery atherosclerosis (LAA) stroke is unclear. This study aims to explore the relationship of poststroke neutrophil count with the functional outcome of patients with LAA stroke, and the relationship of poststroke neutrophil count and craniocervical atherosclerotic stenosis (AS) number in these patients. The AS was defined as ≥ 50% stenosis or occlusion attributed to atherosclerosis on craniocervical large arteries. A total of 297 participants were enrolled in the cohort. In multivariable analyses, neutrophil count [adjusted relative risk (aRR) = 1.23, 95% confidence interval (CI) 1.09-1.40, p = 0.001] was an independent predictor of 90-day poor functional outcome [modified Rankin Scale (mRS) > 2 points]. The neutrophil count was significantly associated with the craniocervical AS number in a multivariable ordinal logistic regression analysis [adjusted odds ratio (aOR) = 1.41, 95% CI 1.16-1.72, p = 0.001]. The poststroke neutrophil count is a valuable predictor of 90-day poor functional outcome of patients with LAA stroke. The poststroke neutrophil count is positively correlated with the craniocervical AS number in these patients.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Graphical representation of the measurement of the infarct size. (A) single lesion; (B) multiple lesions: infarct size was represented with the sum of all largest lesional diameters.
Figure 2
Figure 2
Flow chart of the study selection. LAA indicates large artery atherosclerosis.
Figure 3
Figure 3
Comparisons of the proportions of 90-day poor functional outcome in the groups, which were divided based on the tertiles of craniocervical AS number and poststroke neutrophil count. (A) The proportion of poor outcomes significantly increased with increasing craniocervical AS number (10.7% vs. 23.3% vs. 33.3%, p = 0.003). (B) The proportion of poor outcomes increased with increasing neutrophil count (11.1% vs. 13.0% vs. 45.9%, p < 0.001). The p value was calculated by the chi-square test. p < 0.05 was considered statistically significant. AS indicates atherosclerotic stenosis.
Figure 4
Figure 4
The ROC curve of poststroke neutrophil count in predicting the poor outcome of patients with LAA stroke. LAA indicates large-artery atherosclerosis.
See this image and copyright information in PMC

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References

    1. Gutierrez J, et al. Determinants and outcomes of asymptomatic intracranial atherosclerotic stenosis. J. Am. Coll. Cardio. 2021;78:562–571. doi: 10.1016/j.jacc.2021.05.041. - DOI - PMC - PubMed
    1. Hurford R, et al. Prognosis of asymptomatic intracranial stenosis in patients with transient ischemic attack and minor stroke. JAMA. Neurol. 2020;77:947–954. doi: 10.1001/jamaneurol.2020.1326. - DOI - PMC - PubMed
    1. Smith WS, et al. Significance of large vessel intracranial occlusion causing acuteischemic stroke and TIA. Stroke. 2009;40:3834–3840. doi: 10.1161/STROKEAHA.109.561787. - DOI - PMC - PubMed
    1. Lau AY, Wong KS, Lev M, Furie K, Smith W, Kim AS. Burden of intracranial steno-occlusive lesions on initial computed tomography angiography predicts poor outcome in patients with acute stroke. Stroke. 2013;44:1310–1316. doi: 10.1161/STROKEAHA.111.672741. - DOI - PubMed
    1. Wang Y, et al. Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: The Chinese Intracranial Atherosclerosis (CICAS) Study. Stroke. 2014;45:663–669. doi: 10.1161/STROKEAHA.113.003508. - DOI - PubMed