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. 2023 May 2;8(3):340-349.
doi: 10.1016/j.ncrna.2023.04.002. eCollection 2023 Sep.

Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course

Randa Erfan  1 , Olfat G Shaker  1 , Mahmoud A F Khalil  2 , Aya M AlOrbani  3 , Abeer K Abu-El-Azayem  4 , Amira Samy  5 , Othman M Zaki  6 , Haitham Abdelhamid  7 , Reham Fares  8 , Asmaa Mohammed  8
Affiliations

Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course

Randa Erfan et al. Noncoding RNA Res. .

Abstract

Psoriasis is a persistent inflammatory skin disorder driven by T cells. The disease is characterized by aberrant keratinocytes (KCs) differentiation, epidermal proliferation, and excessive hyperplasia of veins and arteries. The purpose of the study was to identify the levels of circulating lnc-HULC, miR-122, and Sirtuin 1 (SIRT-1) in psoriatic patients, evaluate their possible roles as diagnostic biomarkers, and link their levels with the development of metabolic syndrome during psoriasis progression. This study included 176 participants. The subjects were divided into four groups, with 44 participants in each group. All patients have undergone a complete history taking and clinical examination. Laboratory investigations included Low-density lipoprotein (LDL), High-density lipoprotein (HDL), Triglycerides (TG), Fasting blood sugar (FBS), and cholesterol plasma levels. Serum levels of miR-122 and lnc-HULC were examined by qRT-PCR. Serum levels of SIRT-1 were examined by ELISA. The serum concentrations of lnc-HULC and miR-122 were significantly higher in psoriatic participants compared to controls. Psoriatic patients' serum concentrations of SIRT-1 were much lower than those of healthy individuals. There was a negative association between SIRT-1 concentration and BMI, disease duration, PASI score, LDL, and cholesterol levels. The blood levels of lnc-HULC, miR-122, and SIRT-1 in psoriasis patients provide a promising role as diagnostic biomarkers in patients with and without metabolic syndrome.

Keywords: Lnc-HULC; Metabolic syndrome; MiR-122; Psoriasis; SIRT-1.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
ROC curve for miR-122 and lnc-HULC in diagnosing psoriasis without metabolic syndrome.
Fig. 2
Fig. 2
ROC curve for SIRT-1 in diagnosing psoriasis without metabolic syndrome.
Fig. 3
Fig. 3
ROC curve for miR-122 and lnc-HULC in diagnosing psoriasis with metabolic syndrome.
Fig. 4
Fig. 4
ROC curve for SIRT-1 in diagnosing psoriasis with metabolic syndrome.
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