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Review
. 2023 Sep:165:115141.
doi: 10.1016/j.biopha.2023.115141. Epub 2023 Jul 10.

The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation

Weizhuo Lu  1 , Zhiwu Chen  2 , Jiyue Wen  3
Affiliations
Free article
Review

The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation

Weizhuo Lu et al. Biomed Pharmacother. 2023 Sep.
Free article

Abstract

It is widely known that ischemic stroke is the prominent cause of death and disability. To date, neuroinflammation following ischemic stroke represents a complex event, which is an essential process and affects the prognosis of both experimental stroke animals and stroke patients. Intense neuroinflammation occurring during the acute phase of stroke contributes to neuronal injury, BBB breakdown, and worse neurological outcomes. Inhibition of neuroinflammation may be a promising target in the development of new therapeutic strategies. RhoA is a small GTPase protein that activates a downstream effector, ROCK. The up-regulation of RhoA/ROCK pathway possesses important roles in promoting the neuroinflammation and mediating brain injury. In addition, nuclear factor-kappa B (NF-κB) is another vital regulator of ischemic stroke-induced neuroinflammation through regulating the functions of microglial cells and astrocytes. After stroke onset, the microglial cells and astrocytes are activated and undergo the morphological and functional changes, thereby deeply participate in a complicated neuroinflammation cascade. In this review, we focused on the relationship among RhoA/ROCK pathway, NF-κB and glial cells in the neuroinflammation following ischemic stroke to reveal new strategies for preventing the intense neuroinflammation.

Keywords: Astrocytes; Ischemic stroke; Microglial cells; Neuroinflammation; RhoA/ROCK pathway.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no conflict of interest.

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