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Review
. 2023 Jun 20:13:1176950.
doi: 10.3389/fonc.2023.1176950. eCollection 2023.

Molecular and genetic targets within metastatic colorectal cancer and associated novel treatment advancements

Christopher G Cann  1 , Michael B LaPelusa  1 , Sarah K Cimino  2 , Cathy Eng  1
Affiliations
Review

Molecular and genetic targets within metastatic colorectal cancer and associated novel treatment advancements

Christopher G Cann et al. Front Oncol. .

Abstract

Colorectal cancer results in the deaths of hundreds of thousands of patients worldwide each year, with incidence expected to rise over the next two decades. In the metastatic setting, cytotoxic therapy options remain limited, which is reflected in the meager improvement of patient survival rates. Therefore, focus has turned to the identification of the mutational composition inherent to colorectal cancers and development of therapeutic targeted agents. Herein, we review the most up to date systemic treatment strategies for metastatic colorectal cancer based on the actionable molecular alterations and genetic profiles of colorectal malignancies.

Keywords: EGFR inhibitor; HER2; KRAS; metastatic colorectal cancer; mismatch repair.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart depicting treatment options for mCRC based on tumor mutational status.
See this image and copyright information in PMC

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