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Review
. 2023 Oct;9(10):855-870.
doi: 10.1016/j.trecan.2023.06.004. Epub 2023 Jul 3.

Transcription factor abnormalities in B-ALL leukemogenesis and treatment

Hongxin Yin  1 , Junfei Wang  1 , Yangxia Tan  1 , Minghao Jiang  1 , Hao Zhang  2 , Guoyu Meng  3
Affiliations
Review

Transcription factor abnormalities in B-ALL leukemogenesis and treatment

Hongxin Yin et al. Trends Cancer. 2023 Oct.

Abstract

The biological regulation of transcription factors (TFs) and repressor proteins is an important mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) TF abnormalities occur at high frequency and are often recognized as the major driving factor in carcinogenesis. We provide an in-depth review of molecular mechanisms of six major TF rearrangements in B-ALL, including DUX4-rearranged (DUX4-R), MEF2D-R, ZNF384-R, ETV6-RUNX1 and TCF3-PBX1 fusions, and KMT2A-R. In addition, the therapeutic options and prognoses for patients who harbor these TF abnormalities are discussed. This review aims to provide an up-to-date panoramic view of how TF-based oncogenic fusions might drive carcinogenesis and impact on potential therapeutic exploration of B-ALL treatments.

Keywords: B cell acute lymphoblastic leukemia (B-ALL); oncogenic fusions; targeted therapy; transcription factor.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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