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Review
. 2023 May 12;21(5):367-378.
doi: 10.18502/ijrm.v21i5.13470. eCollection 2023 May.

Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis

Seyed Sobhan Bahreiny  1 , Elnaz Harooni  1 , Mohammad Reza Dabbagh  2 , Reza Ebrahimi  3
Affiliations
Review

Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis

Seyed Sobhan Bahreiny et al. Int J Reprod Biomed. .

Abstract

Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders.

Objective: This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS.

Materials and methods: A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity.

Results: The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI]: 0.63-2.08; p < 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% CI: 1.17-3.63; p < 0.001) within the subgroup.

Conclusion: Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results.

Keywords: Preptin, Meta-analysis.; Proinsulin-like growth factor II; Polycystic ovary syndrome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of study selection adjusted by prisma.
Figure 2
Figure 2
The forest plots comparing serum preptin levels between PCOS and control groups.
Figure 3
Figure 3
Forest plot of body mass index ≥ 25 kg/m2 and body mass index ≤ 25 kg/m2 in subgroup analysis.
Figure 4
Figure 4
Forest plot of age ≥ 25 yr and age ≤ 25 yr in subgroup analysis.
Figure 5
Figure 5
Forest plot of positive/negative HOMA-IR in subgroup analysis.
Figure 6
Figure 6
Meta-regression of serum preptin levels in women with PCOS.
Figure 7
Figure 7
Funnel plot of standard error by standard differences in the means of serum preptin level.
See this image and copyright information in PMC

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