Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul;72(7):1501-1512.
doi: 10.1007/s00011-023-01760-w. Epub 2023 Jun 23.

SHP2: its association and roles in systemic lupus erythematosus

Chan Yang #  1 , Rong Li #  1 , Lin-Chong Su #  2 , You-Yu Lan  3 , You-Qiang Wang  4 , Wang-Dong Xu  5 , An-Fang Huang  6
Affiliations

SHP2: its association and roles in systemic lupus erythematosus

Chan Yang et al. Inflamm Res. 2023 Jul.

Abstract

Objective: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease. Src homology 2 domain containing protein tyrosine phosphatase (SHP2) is a member of the protein tyrosine phosphatases (PTPs) family. To date, relationship between SHP2 and SLE pathogenesis is not elucidated.

Method: We measured plasma levels of SHP2 in 328 SLE patients, 78 RA patients, 80 SS patients and 79 healthy controls by ELISA, and discussed association of SHP2 in SLE patients, potential of plasma SHP2 as a SLE biomarker. Moreover, histological and serological changes were evaluated by flow cytometry, HE/Masson examination, immunofluorescence test in pristane-induced lupus mice after SHP2 inhibitor injection to reveal role of SHP2 in lupus development.

Results: Results indicated that SHP2 plasma levels were upregulated in SLE patients and correlated with some clinical, laboratory characteristics such as proteinuria, pyuria, and may be a potential biomarker for SLE. After SHP2 inhibitor treatment, hepatosplenomegaly and histological severity of the kidney in lupus mice were improved. SHP2 inhibitor reversed DCs, Th1, and Th17 cells differentiation and downregulated inflammatory cytokines (IL-4, IL-6, IL-10, IL-17A, IFN-γ and TNF-α) and autoantibodies (ANA, anti-dsDNA) production in pristane-lupus mice.

Conclusion: In summary, SHP2 correlated with SLE pathogenesis and promoted the development of lupus.

Keywords: Autoimmunity; Inflammation; Lupus; SHP2.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Yang C, et al. Increased levels of sirtuin-1 in systemic lupus erythematosus. Int J Rheum Dis. 2022;25(8):869–76. - PubMed - DOI
    1. Ci W, et al. Characteristics and risk factors of severe coronary artery disease in systemic lupus erythematosus: a multicenter, Chinese Rheumatism Date Center database study. Int J Rheum Dis. 2022;25(10):1186–95. - PubMed - DOI
    1. Chen Y. Systemic lupus erythematosus increases risk of incident atrial fibrillation: a systematic review and meta-analysis. Int J Rheum Dis. 2022;25(10):1097–106. - PubMed - DOI
    1. Sakata K, et al. Up-regulation of TLR7-mediated IFN-α production by plasmacytoid dendritic cells in patients with systemic lupus erythematosus. Front Immunol. 2018;9:1957. - PubMed - PMC - DOI
    1. Ravetch JV, Bolland S. IgG Fc receptors. Annu Rev Immunol. 2001;19:275–90. - PubMed - DOI

LinkOut - more resources