Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms

doi:10.1186/s13099-023-00547-y

Review

. 2023 Jun 12;15(1):27.

doi: 10.1186/s13099-023-00547-y.

Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms

Biqing Huang^{1

2

3}, Jianwei Wang³, Lanjuan Li⁴

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University school of medicine, Hangzhou, China.
² Research Units of Infectious disease and Microecology, Chinese Academy of Medical Sciences & Peking Union Medical College, Hangzhou, China.
³ NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
⁴ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University school of medicine, Hangzhou, China. ljli@zju.edu.cn.

PMID: 37308966
PMCID: PMC10258485
DOI: 10.1186/s13099-023-00547-y

Review

Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms

Biqing Huang et al. Gut Pathog. 2023.

. 2023 Jun 12;15(1):27.

doi: 10.1186/s13099-023-00547-y.

Authors

Biqing Huang^{1

2

3}, Jianwei Wang³, Lanjuan Li⁴

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University school of medicine, Hangzhou, China.
² Research Units of Infectious disease and Microecology, Chinese Academy of Medical Sciences & Peking Union Medical College, Hangzhou, China.
³ NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
⁴ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University school of medicine, Hangzhou, China. ljli@zju.edu.cn.

PMID: 37308966
PMCID: PMC10258485
DOI: 10.1186/s13099-023-00547-y

Erratum in

Correction: Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms.
Huang B, Wang J, Li L. Huang B, et al. Gut Pathog. 2023 Jul 10;15(1):34. doi: 10.1186/s13099-023-00560-1. Gut Pathog. 2023. PMID: 37424033 Free PMC article. No abstract available.

Abstract

Vaccine is the most effective way to prevent the spread of communicable diseases, but the immune response induced by it varies greatly between individuals and populations in different regions of the world. Current studies have identified the composition and function of the gut microbiota as key factors in modulating the immune response to vaccination. This article mainly reviews the differences in gut microbiota among different groups of vaccinated people and animals, explores the possible mechanism of vaccine immunity affected by gut microbiota, and reviews the strategies for targeting gut microbiota to improve vaccine efficacy.

Keywords: Gut microbiota; Immune efficacy; Vaccine.

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Conflict of interest statement

The authors declare no competing financial interests.

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Correction: Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms.
Huang B, Wang J, Li L. Huang B, et al. Gut Pathog. 2023 Jul 10;15(1):34. doi: 10.1186/s13099-023-00560-1. Gut Pathog. 2023. PMID: 37424033 Free PMC article. No abstract available.
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References

1. Lynn DJ, Benson SC, Lynn MA, et al. Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms[J] Nat Rev Immunol. 2022;22(1):33–46. doi: 10.1038/s41577-021-00554-7. - DOI - PMC - PubMed
1. de Jong SE, Olin A, Pulendran B. The impact of the Microbiome on immunity to vaccination in Humans[J] Cell Host Microbe. 2020;28(2):169–79. doi: 10.1016/j.chom.2020.06.014. - DOI - PMC - PubMed
1. Jordan A, Carding SR, Hall LJ. The early-life gut microbiome and vaccine efficacy[J] Lancet Microbe. 2022;3(10):e787–94. doi: 10.1016/s2666-5247(22)00185-9. - DOI - PubMed
1. Swaminathan G, Citron M, Xiao J, et al. Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in mice and non-human Primates is diminished upon recovery of the gut Microbiome[J]. Vaccines (Basel). 2021;9(11). 10.3390/vaccines9111340. PubMed 34835271. - PMC - PubMed
1. Lynn MA, Tumes DJ, Choo JM, et al. Early-Life Antibiotic-Driven Dysbiosis leads to Dysregulated Vaccine Immune responses in Mice[J] Cell Host Microbe. 2018;23(5):653–660e655. doi: 10.1016/j.chom.2018.04.009. - DOI - PubMed

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[1] Lynn DJ, Benson SC, Lynn MA, et al. Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms[J] Nat Rev Immunol. 2022;22(1):33–46. doi: 10.1038/s41577-021-00554-7. - DOI - PMC - PubMed

[2] Lynn DJ, Benson SC, Lynn MA, et al. Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms[J] Nat Rev Immunol. 2022;22(1):33–46. doi: 10.1038/s41577-021-00554-7. - DOI - PMC - PubMed

[3] de Jong SE, Olin A, Pulendran B. The impact of the Microbiome on immunity to vaccination in Humans[J] Cell Host Microbe. 2020;28(2):169–79. doi: 10.1016/j.chom.2020.06.014. - DOI - PMC - PubMed

[4] de Jong SE, Olin A, Pulendran B. The impact of the Microbiome on immunity to vaccination in Humans[J] Cell Host Microbe. 2020;28(2):169–79. doi: 10.1016/j.chom.2020.06.014. - DOI - PMC - PubMed

[5] Jordan A, Carding SR, Hall LJ. The early-life gut microbiome and vaccine efficacy[J] Lancet Microbe. 2022;3(10):e787–94. doi: 10.1016/s2666-5247(22)00185-9. - DOI - PubMed

[6] Jordan A, Carding SR, Hall LJ. The early-life gut microbiome and vaccine efficacy[J] Lancet Microbe. 2022;3(10):e787–94. doi: 10.1016/s2666-5247(22)00185-9. - DOI - PubMed

[7] Swaminathan G, Citron M, Xiao J, et al. Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in mice and non-human Primates is diminished upon recovery of the gut Microbiome[J]. Vaccines (Basel). 2021;9(11). 10.3390/vaccines9111340. PubMed 34835271. - PMC - PubMed

[8] Swaminathan G, Citron M, Xiao J, et al. Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in mice and non-human Primates is diminished upon recovery of the gut Microbiome[J]. Vaccines (Basel). 2021;9(11). 10.3390/vaccines9111340. PubMed 34835271. - PMC - PubMed

[9] Lynn MA, Tumes DJ, Choo JM, et al. Early-Life Antibiotic-Driven Dysbiosis leads to Dysregulated Vaccine Immune responses in Mice[J] Cell Host Microbe. 2018;23(5):653–660e655. doi: 10.1016/j.chom.2018.04.009. - DOI - PubMed

[10] Lynn MA, Tumes DJ, Choo JM, et al. Early-Life Antibiotic-Driven Dysbiosis leads to Dysregulated Vaccine Immune responses in Mice[J] Cell Host Microbe. 2018;23(5):653–660e655. doi: 10.1016/j.chom.2018.04.009. - DOI - PubMed

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Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms

Affiliations

Recent five-year progress in the impact of gut microbiota on vaccination and possible mechanisms

Authors

Affiliations

Erratum in

Abstract

Conflict of interest statement

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Erratum in

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Conflict of interest statement

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