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Review
. 2023 Jul;62(7):705-710.
doi: 10.1007/s00120-023-02121-5. Epub 2023 Jun 12.

[New antibiotics for the treatment of urinary tract infections]

[Article in German]
Florian M E Wagenlehner  1
Affiliations
Review

[New antibiotics for the treatment of urinary tract infections]

[Article in German]
Florian M E Wagenlehner. Urologie. 2023 Jul.

Abstract
in English, German

Urinary tract infections (UTIs) are among the most common bacterial infections. The clinical phenotypes of UTIs are heterogeneous, ranging from rather benign uncomplicated infections to complicated UTIs and pyelonephritis to severe urosepsis. Antibiotics have become indispensable in modern medicine, but the development of resistance is threatening clinical effectiveness. Antimicrobial resistance rates are locally high in UTIs, however can vary significantly depending on the population studied and the type of study. In addition, between 1990 and 2010, there was a discovery void in the development of new antibiotics that is still having an impact today. In recent years, UTIs have emerged as an infection model for research into novel antibiotics. In the last 10 years, novel gram-negative active drugs have been explored in these groups. On the one hand, novel beta-lactam/beta-lactamase inhibitor combinations were investigated, and there has also been further development of cephalosporins and aminoglycosides.

Harnwegsinfektionen (HWI) gehören zu den häufigsten bakteriellen Infektionen. Die klinischen Phänotypen der HWI sind heterogen und reichen von eher gutartigen unkomplizierten Infektionen über komplizierte HWI und Pyelonephritis bis hin zu schwerer Urosepsis. Antibiotika sind aus der modernen Medizin nicht mehr wegzudenken, aber Resistenzentwicklung bedroht die klinische Effektivität. Antimikrobielle Resistenzraten sind bei HWI stellenweise hoch, können sich jedoch erheblich unterscheiden, je nach untersuchter Population und Studienart. Zusätzlich manifestierte sich in den Jahren 1990 bis 2010 eine Antibiotikaentwicklungslücke, die auch heute noch nachwirkt. HWI haben sich in den letzten Jahren als Infektionsmodell für die Erforschung neuartiger Antibiotika herausgestellt. In den letzten 10 Jahren wurden neuartige gramnegative Wirkstoffe in diesen Gruppen beforscht. Zum einen wurden neuartige Beta-Laktam/Beta-Laktamasehemmerkombinationen untersucht sowie Weiterentwicklungen von Cephalosporinen und Aminoglykosiden.

Keywords: Bacterial drug resistance; Beta-lactamases; Carbapenems; Cephalosporins; Microbial drug resistance.

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References

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