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. 2023 Sep;13(3):476-484.
doi: 10.1007/s44197-023-00126-z. Epub 2023 Jun 10.

Assessment of the Impact of the Rotavirus Vaccine Against Severe Rotaviral Diarrhea in Uzbekistan

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Assessment of the Impact of the Rotavirus Vaccine Against Severe Rotaviral Diarrhea in Uzbekistan

Erkin Musabaev et al. J Epidemiol Glob Health. 2023 Sep.

Abstract

Background: This article presents the results of a long-term study of the impact of rotavirus vaccination in Uzbekistan. Uzbekistan is the first country in the Central Asian region to introduce rotavirus vaccination into the national compulsory vaccination calendar. The study aimed to evaluate the impact of rotavirus vaccination on hospitalizations due to all-cause AGE and RVGE in children < 5 years of age in Uzbekistan.

Methods: Detection of rotavirus antigen was performed using Rotavirus-Antigen-IFA-BEST "Vector Best" kit (Novosibirsk, Russia).

Results: The total of 20,128 children under 5 years of age were hospitalized in sentinel hospitals with a diagnosis of acute gastroenteritis during the study period (2019-2020). Of this number of children, 4481 children (22.2%) were included in the study. Of 4481 children, 367 (8.2%) children tested positive for rotavirus. In our study, decrease in the rotavirus rate was noted in all age groups. The peak of rotavirus positivity occurred in the months of January and February.

Conclusion: The average rotavirus-positive rate in the period (2019-2020) was 8.2% and the absolute percentage decrease was 18.1% compared to the pre-vaccination period (2005-2009) where the rotavirus-positive rate was 26.3%. The percentage of prevented cases averaged 68.8%.

Keywords: AGE; Bukhara; RVGE; Rotavirus; Tashkent; UMV; Vaccination.

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Conflict of interest statement

The authors declare that they have no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Written informed consent was collected from all participants. Anonymity and confidentiality were confirmed.

Figures

Fig. 1
Fig. 1
The incidence of RVGE (A.08.0) among hospitalized with AGE (A.09) in children under 5 years of age
Fig. 2
Fig. 2
Seasonal distribution of cases of rotavirus gastroenteritis before and after vaccination (Note: time gaps from 2010 to 2013 and 2018 because not tested for RVGE)

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