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Review
. 2023 May 29:2023:8831804.
doi: 10.1155/2023/8831804. eCollection 2023.

Updates on the Status of Carbapenem-Resistant Enterobacterales in Lebanon

Mahdi Fadlallah  1 , Ahmad Salman  2 , Elie Salem-Sokhn  3
Affiliations
Review

Updates on the Status of Carbapenem-Resistant Enterobacterales in Lebanon

Mahdi Fadlallah et al. Int J Microbiol. .

Abstract

Carbapenem-resistant Enterobacterales (CRE) pathogens have been increasingly isolated and reported in Lebanon. Several studies have been published over the last two decades about the CRE situation in the country. However, compared to the worldwide data, those studies are scarce and mostly restricted to single center studies. In this review, we aim to present a comprehensive and reliable report illustrating the current situation regarding CRE in Lebanon. Variable studies have shown an increasing pattern of carbapenem resistance in Enterobacterales since the first reports of CRE isolates in 2007 and 2008. Escherichia coli and Klebsiella pneumoniae were the most detected ones. The OXA-48 class D carbapenemases were the most prevalent carbapenemases among CRE isolates. Moreover, the emergence of other carbapenemases like the NDM class B carbapenemase has been noticed. Strict infection control measures in hospitals, including the identification of CRE carriers, are needed in Lebanese hospitals since carriage is a potential risk for the spread of CRE in healthcare settings. The dissemination of CRE in the community is noticed and attributed to multiple causes, such as the refugee crisis, water contamination, and antimicrobial misuse. In conclusion, strict infection control measures in healthcare settings, in addition to accurate antimicrobial stewardship program implementation, are urgently needed.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Classification of carbapenemases β-lactamases that confer resistance to carbapenems in Enterobacterales (reference 5). KPC: Klebsiella pneumoniae carbapenemase; IMP: imipenemase metallo-β-lactamase; NDM: New Delhi metallo-β-lactamase; NMC: nonmetallocarbapenemase; OXA: oxacillin carbapenemase/oxacillinase; SME: Serratia marcescens enzyme; VIM: Verona integron-encoded metallo-β-lactamase.
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