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Review
. 2023 May 22;15(5):1560.
doi: 10.3390/pharmaceutics15051560.

Transforming Wound Management: Nanomaterials and Their Clinical Impact

Ashwini T  1 , Ashlesh Prabhu  1 , Vishal Baliga  1 , Shreesha Bhat  1 , Siddarth T Thenkondar  1 , Yogendra Nayak  2 , Usha Y Nayak  1
Affiliations
Review

Transforming Wound Management: Nanomaterials and Their Clinical Impact

Ashwini T et al. Pharmaceutics. .

Abstract

Wound healing is a complex process that can be further complicated in chronic wounds, leading to prolonged healing times, high healthcare costs, and potential patient morbidity. Nanotechnology has shown great promise in developing advanced wound dressings that promote wound healing and prevent infection. The review article presents a comprehensive search strategy that was applied to four databases, namely Scopus, Web of Science, PubMed, and Google Scholar, using specific keywords and inclusion/exclusion criteria to select a representative sample of 164 research articles published between 2001 and 2023. This review article provides an updated overview of the different types of nanomaterials used in wound dressings, including nanofibers, nanocomposites, silver-based nanoparticles, lipid nanoparticles, and polymeric nanoparticles. Several recent studies have shown the potential benefits of using nanomaterials in wound care, including the use of hydrogel/nano silver-based dressings in treating diabetic foot wounds, the use of copper oxide-infused dressings in difficult-to-treat wounds, and the use of chitosan nanofiber mats in burn dressings. Overall, developing nanomaterials in wound care has complemented nanotechnology in drug delivery systems, providing biocompatible and biodegradable nanomaterials that enhance wound healing and provide sustained drug release. Wound dressings are an effective and convenient method of wound care that can prevent wound contamination, support the injured area, control hemorrhaging, and reduce pain and inflammation. This review article provides valuable insights into the potential role of individual nanoformulations used in wound dressings in promoting wound healing and preventing infections, and serves as an excellent resource for clinicians, researchers, and patients seeking improved healing outcomes.

Keywords: bandages; lipid nanoparticles; nanocomposites; nanofibers; nanomaterials; polymeric nanoparticles; silver-based nanoparticles; wound care.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Year-wise bibliometric distribution data.
Figure 2
Figure 2
Normal wound healing process [36]. (A) Hemostasis—platelet aggregation and clotting cascade. (B) Inflammation—Inflammatory responses and autolysis by macrophages, neutrophils, and mast cells. (C) Proliferation—Fibroblast formation, epithelial cell regeneration, granulation, contraction, and angiogenesis. (D) Remodeling—Collagen remodeling from Type-III to Type-I.
Figure 3
Figure 3
Nanocomposite-impregnated dressing for wound treatment; (1) Inflammatory response: skin wound. (2) Wound treated with nanocomposite loaded dressing. (3) Healed wound.
Figure 4
Figure 4
Synthesis of cerium oxide nanoparticle-impregnated gel [148]. Synthesis of cerium oxide nanoparticle using wet chemical method. Surfaces of nanoparticles were functionalized with miRNA146a. The functionalized nanoparticles were incorporated into gel, and the developed formulation was characterized.
See this image and copyright information in PMC

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