Improved Survival of Young Patients With Breast Cancer 40 Years and Younger at Diagnosis
- PMID: 37229627
- PMCID: PMC10497296
- DOI: 10.1200/GO.22.00354
Improved Survival of Young Patients With Breast Cancer 40 Years and Younger at Diagnosis
Abstract
Purpose: Around 50% of patients with breast cancer in low- or middle-income countries are younger than 50 years, a poor prognostic variable. We report the outcome of patients with breast cancer 40 years and younger.
Methods: We reviewed 386 patients with breast cancer 40 years and younger and retrieved demographic, clinicopathologic, treatment-related, disease progression, and survival data from electronic medical records.
Results: The median age at diagnosis was 36 years, and infiltrating ductal carcinoma was present in 94.3% of patients, infiltrating lobular carcinoma in 1.3%, and ductal carcinoma in situ in 4.4%. Grade 1 disease was present in 8.5% of patients, grade 2 in 35.5%, and grade 3 in 53.4%; 25.1% had human epidermal growth factor receptor 2 (HER2)-positive, 74.6% had hormone receptor (HR)+, and 16.6% had triple-negative breast cancer. Early breast cancer (EBC) constituted 63.6% (stage I, 22.4%; stage II, 41.2%) of patients, whereas 23.2% had stage III, and 13.2% had metastatic disease at diagnosis. Of patients with EBC, 51% had partial mastectomy and 49.0% had total mastectomy. And 77.1% had chemotherapy with or without anti-HER2 therapy. All HR+ patients received adjuvant hormonal therapy. The disease-free survival at 5 years was 72.5% and 55.9% at 10 years. The overall survival (OS) was 89.4% at 5 years and 76% at 10 years. Patients with stages I/II had an OS of 96.0% at 5 years and 87.1% at 10 years. Patients with stage III had an OS of 88.3% at 5 years and 68.7% at 10 years. The OS of patients with stage IV was 64.5% at 5 years and 48.4% at 10 years.
Conclusion: We report survival rates of 89% at 5 years and 76% at 10 years with modern multidisciplinary management. Best results were seen in EBC: OS rates of 96% and 87% at 5 years and 10 years.
Conflict of interest statement
The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to
Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (
Figures
Similar articles
-
Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes.Ann Oncol. 2014 Feb;25(2):384-91. doi: 10.1093/annonc/mdt525. Epub 2013 Dec 18. Ann Oncol. 2014. PMID: 24351399 Free PMC article.
-
Risk and prognostic factors of breast cancer with liver metastases.BMC Cancer. 2021 Mar 6;21(1):238. doi: 10.1186/s12885-021-07968-5. BMC Cancer. 2021. PMID: 33676449 Free PMC article.
-
Female patients with breast carcinoma age 30 years and younger have a poor prognosis: the M.D. Anderson Cancer Center experience.Cancer. 2001 Nov 15;92(10):2523-8. doi: 10.1002/1097-0142(20011115)92:10<2523::aid-cncr1603>3.0.co;2-6. Cancer. 2001. PMID: 11745185
-
Relative effectiveness of adjuvant chemotherapy for invasive lobular compared with invasive ductal carcinoma of the breast.Cancer. 2017 Aug 15;123(16):3015-3021. doi: 10.1002/cncr.30699. Epub 2017 Apr 5. Cancer. 2017. PMID: 28382636
-
An overview of triple-negative breast cancer.Arch Gynecol Obstet. 2016 Feb;293(2):247-69. doi: 10.1007/s00404-015-3859-y. Epub 2015 Sep 4. Arch Gynecol Obstet. 2016. PMID: 26341644 Review.
Cited by
-
Factors Influencing Surgical Choices in Breast Cancer Treatment in India: A Comparative Study of Breast-Conserving Surgery vs Mastectomy.Cureus. 2024 Aug 13;16(8):e66825. doi: 10.7759/cureus.66825. eCollection 2024 Aug. Cureus. 2024. PMID: 39280530 Free PMC article.
-
Sexual quality of life of adolescents and young adult breast cancer survivors.ESMO Open. 2024 Feb;9(2):102234. doi: 10.1016/j.esmoop.2024.102234. Epub 2024 Jan 27. ESMO Open. 2024. PMID: 38281325 Free PMC article.
-
The influence of chronic renal insufficiency on multi-therapeutic modalities for breast cancer: a single-center experience.Breast Cancer. 2024 Mar;31(2):252-262. doi: 10.1007/s12282-023-01530-w. Epub 2023 Dec 27. Breast Cancer. 2024. PMID: 38150135 Free PMC article.
-
Current status of fertility preservation in a Spanish tertiary public hospital: multidisciplinary approach and experience in over 1500 patients.Clin Transl Oncol. 2024 May;26(5):1129-1138. doi: 10.1007/s12094-023-03330-2. Epub 2023 Oct 23. Clin Transl Oncol. 2024. PMID: 37872422
References
-
- Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–249. - PubMed
-
- Partridge AH, Hughes ME, Warner ET, et al. Subtype-dependent relationship between young age at diagnosis and breast cancer survival. J Clin Oncol. 2016;34:3308–3314. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous