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. 2023 Apr;75(Suppl 1):755-763.
doi: 10.1007/s12070-022-03205-y. Epub 2022 Dec 8.

A Review on the Nasal Microbiome and Various Disease Conditions for Newer Approaches to Treatments

Saurav Sarkar  1 , Samapika Routhray  2 , Balamurugan Ramadass  3 , Pradipta Kumar Parida  1
Affiliations

A Review on the Nasal Microbiome and Various Disease Conditions for Newer Approaches to Treatments

Saurav Sarkar et al. Indian J Otolaryngol Head Neck Surg. 2023 Apr.

Abstract

Introduction: Commensal bacteria have always played a significant role in the maintenance of health and disease but are being unravelled only recently. Studies suggest that the nasal microbiome has a significant role in the development of various disease conditions. Search engines were used for searching articles having a nasal microbiome and disease correlation. In olfactory dysfunction, dysbiosis of the microbiome may have a significant role to play in the pathogenesis. The nasal microbiome influences the phenotype of CRS and is also capable of modulating the immune response and plays a role in polyp formation. Microbiome dysbiosis has a pivotal role in the development of Allergic Rhinitis; but, yet known how is this role played. The nasal microbiome has a close association with the severity and phenotype of asthma. They contribute significantly to the onset, severity, and development of asthma. The nasal microbiome has a significant impact on the immunity and protection of its host. The nasal microbiome has been a stimulus in the development of Otitis Media and its manifestations. Studies suggest that the resident nasal microbiome is responsible for the initiation of neurodegenerative diseases like Parkinson's Disease.Materials and Methods: Literature search from PubMed, Medline, and Google with the Mesh terms: nasal microbiome AND diseases. Conclusion: With increasing evidence on the role of the nasal microbiome on various diseases, it would be interesting to see how this microbiome can be modulated by pro/pre/post biotics to prevent a disease or the severity of illness.

Keywords: Nasal microbiome; dysbiosis; new approach to therapy.

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Conflict of interest statement

Conflict of InterestNone.

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References

    1. Noecker C, McNally CP, Eng A, Borenstein E. High-resolutioncharacterization of the human microbiome. Transl Res. 2017;179:7–23. doi: 10.1016/j.trsl.2016.07.012. - DOI - PMC - PubMed
    1. Desrosiers M, Valera FC. Brave New (Microbial) World: implications for nasal and sinus disorders. Braz JOtorhinolaryngol. 2019;85:675–677. doi: 10.1016/j.bjorl.2019.09.001. - DOI - PMC - PubMed
    1. Barko PC, McMichael M, Swanson KS, Williams DA. The gastrointestinal microbiome: a review. J Vet Intern Med. 2018;32:9–25. doi: 10.1111/jvim.14875. - DOI - PMC - PubMed
    1. Gupta VK, Paul S, Dutta C, Geography Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity. Front Microbiol. 2017;8:1162. doi: 10.3389/fmicb.2017.01162. - DOI - PMC - PubMed
    1. de Steenhuijsen Piters WAA, Sanders EAM, Bogaert D. The role of the local microbial ecosystem in respiratory health and disease. Philos Trans R Soc B Biol Sci. 2015;370:20140294. doi: 10.1098/rstb.2014.0294;. - DOI - PMC - PubMed

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