A preoperative nomogram model for the prediction of lymph node metastasis in buccal mucosa cancer
- PMID: 37184116
- PMCID: PMC10358226
- DOI: 10.1002/cam4.6076
A preoperative nomogram model for the prediction of lymph node metastasis in buccal mucosa cancer
Abstract
Objectives: We sought to construct a nomogram model predicting lymph node metastasis (LNM) in patients with squamous cell carcinoma of the buccal mucosa based on preoperative clinical characteristics.
Methods: Patients who underwent radical resection of a primary tumor in the buccal mucosa with neck dissection were enrolled. Clinical characteristics independently associated with LNM in multivariate analyses were adopted to build the model. Patients at low risk of LNM were defined by a predicted probability of LNM of less than 5%.
Results: Patients who underwent surgery in an earlier period (January 2015-November 2019) were defined as the model development cohort (n = 325), and those who underwent surgery later (November 2019-March 2021) were defined as the validation cohort (n = 140). Age, tumor differentiation, tumor thickness, and clinical N stage assessed by computed tomography/magnetic resonance imaging (cN) were independent predictors of LNM. The nomogram model based on these four predictors showed good discrimination accuracy in both the model development and validation cohorts, with areas under the receiver-operating characteristic curve (AUC) of 0.814 and 0.828, respectively. LNM prediction by the nomogram model was superior to cN in AUC comparisons (0.815 vs. 0.753) and decision curve analysis of the whole cohort. Seventy-one patients were defined as having a low risk of LNM, among whom the actual metastasis rate was only 1.4%.
Conclusions: A robust nomogram model for preoperative LNM prediction is built.
Keywords: buccal mucosa carcinoma; lymph node metastasis; nomogram.
© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Figures
Similar articles
-
[A nomogram for predicting lymph node metastasis in early gastric cancer].Zhonghua Wei Chang Wai Ke Za Zhi. 2022 Jan 25;25(1):40-47. doi: 10.3760/cma.j.cn441530-20210208-00059. Zhonghua Wei Chang Wai Ke Za Zhi. 2022. PMID: 35067033 Chinese.
-
A Comprehensive Nomogram Combining CT Imaging with Clinical Features for Prediction of Lymph Node Metastasis in Stage I-IIIB Non-small Cell Lung Cancer.Ther Innov Regul Sci. 2022 Jan;56(1):155-167. doi: 10.1007/s43441-021-00345-1. Epub 2021 Oct 26. Ther Innov Regul Sci. 2022. PMID: 34699046
-
Nomogram for prediction of lymph node metastasis in patients with superficial esophageal squamous cell carcinoma.J Gastroenterol Hepatol. 2020 Jun;35(6):1009-1015. doi: 10.1111/jgh.14915. Epub 2019 Dec 15. J Gastroenterol Hepatol. 2020. PMID: 31674067
-
Nomograms for intraoperative prediction of lymph node metastasis in clinical stage IA lung adenocarcinoma.Cancer Med. 2023 Jul;12(13):14360-14374. doi: 10.1002/cam4.6115. Epub 2023 May 22. Cancer Med. 2023. PMID: 37212495 Free PMC article.
-
A predictive nomogram for lymph node metastasis of incidental gallbladder cancer: a SEER population-based study.BMC Cancer. 2020 Aug 31;20(1):828. doi: 10.1186/s12885-020-07341-y. BMC Cancer. 2020. PMID: 32867722 Free PMC article.
References
-
- Sarode G, Maniyar N, Sarode SC, Jafer M, Patil S, Awan KH. Epidemiologic aspects of oral cancer. Dis Mon. 2020;66(12):100988. - PubMed
-
- Liao CT, Huang SF, Chen IH, et al. Tongue and buccal mucosa carcinoma: is there a difference in outcome? Ann Surg Oncol. 2010;17(11):2984‐2991. - PubMed
-
- Jan JC, Hsu WH, Liu SA, et al. Prognostic factors in patients with buccal squamous cell carcinoma: 10‐year experience. J Oral Maxillofac Surg. 2011;69(2):396‐404. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical