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Review
. 2023 Aug;15(4):983-1000.
doi: 10.1007/s12602-023-10087-1. Epub 2023 May 12.

Mechanistic Insights into Immune-Microbiota Interactions and Preventive Role of Probiotics Against Autoimmune Diabetes Mellitus

M Bidyarani Devi  1   2 , Hridip Kumar Sarma  2 , Ashis K Mukherjee  1 , Mojibur R Khan  3
Affiliations
Review

Mechanistic Insights into Immune-Microbiota Interactions and Preventive Role of Probiotics Against Autoimmune Diabetes Mellitus

M Bidyarani Devi et al. Probiotics Antimicrob Proteins. 2023 Aug.

Abstract

Recent studies on genetically susceptible individuals and animal models revealed the potential role of the intestinal microbiota in the pathogenesis of type 1 diabetes (T1D) through complex interactions with the immune system. T1D incidence has been increasing exponentially with modern lifestyle altering normal microbiota composition, causing dysbiosis characterized by an imbalance in the gut microbial community. Dysbiosis has been suggested to be a potential contributing factor in T1D. Moreover, several studies have shown the potential role of probiotics in regulating T1D through various mechanisms. Current T1D therapies target curative measures; however, preventive therapeutics are yet to be proven. This review highlights immune microbiota interaction and the immense role of probiotics and postbiotics as important immunological interventions for reducing the risk of T1D.

Keywords: Gut microbiota; Immune system; Inflammation; Probiotics; Type 1 diabetes.

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