A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights

doi:10.1016/j.heliyon.2023.e15346

Review

. 2023 Apr 14;9(5):e15346.

doi: 10.1016/j.heliyon.2023.e15346. eCollection 2023 May.

A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights

Sanchita Dewanjee¹, Md Sohel^{2

3}, Md Shahadat Hossain⁴, Farzana Ansari⁵, Md Tofikul Islam⁴, Farhana Sultana^{3

4}, Abdullah Al Mamun², Md Monirul Islam⁶, Mohammad Nurul Amin^{3

4}

Affiliations

¹ Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh.
² Department of Biochemistry and Molecular Biology, Primeasia University, Banani, Dhaka, 1213, Bangladesh.
³ Pratyasha Health Biomedical Research Center, Dhaka, 1230, Bangladesh.
⁴ Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh.
⁵ Department of Biochemistry and Molecular Biology, Laboratory of Nutrition and Health Research, University of Dhaka, Dhaka, 1000, Bangladesh.
⁶ Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh.

PMID: 37159686
PMCID: PMC10163606
DOI: 10.1016/j.heliyon.2023.e15346

Review

A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights

Sanchita Dewanjee et al. Heliyon. 2023.

. 2023 Apr 14;9(5):e15346.

doi: 10.1016/j.heliyon.2023.e15346. eCollection 2023 May.

Authors

Sanchita Dewanjee¹, Md Sohel^{2

3}, Md Shahadat Hossain⁴, Farzana Ansari⁵, Md Tofikul Islam⁴, Farhana Sultana^{3

4}, Abdullah Al Mamun², Md Monirul Islam⁶, Mohammad Nurul Amin^{3

4}

Affiliations

¹ Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh.
² Department of Biochemistry and Molecular Biology, Primeasia University, Banani, Dhaka, 1213, Bangladesh.
³ Pratyasha Health Biomedical Research Center, Dhaka, 1230, Bangladesh.
⁴ Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh.
⁵ Department of Biochemistry and Molecular Biology, Laboratory of Nutrition and Health Research, University of Dhaka, Dhaka, 1000, Bangladesh.
⁶ Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh.

PMID: 37159686
PMCID: PMC10163606
DOI: 10.1016/j.heliyon.2023.e15346

Abstract

Introduction: People are treating their neuropathic pain with several approved and licensed pharmacological drugs. But due to having existing limitations like low efficacy with some side effects, there needs to be a more effective alternative and complementary therapeutic options.

Purpose: s: The study was designed to discuss the mechanistic role of several clinically proven natural products that have been shown to play a significant role against different nerve pain or neuropathic pain.

Method: ology: Information for this review article was salvaged using several accessible searching databases like SciVerse Scopus ® (Elsevier Properties S. A, USA), Web of Science® (Thomson Reuters, USA), and PubMed® (U.S. National Library of Medicine, USA) considering some search items like - nerve pain, natural products in pain/nerve pain management, clinically proven natural products in pain management, pain-reducing agents and so on.

Result: Our study reported the therapeutic efficacy of natural products and their possible mechanism against neuropathic pain in the human body. Natural products widely used to treat neuropathic pain include comfrey root extract ointment, lavender oil, Rose Oil, aromatic essential oil, ginger oil, vitex agnus-castus, peganum oil, and ajwain 10%. Some common pathways are involved in pain relief through sensory stimulation, enzymatic, anti-inflammatory, and pain-related receptor regulation.

Conclusion: The present study suggests that the mentioned natural products can be an appropriate choice for the treatment and management of neuropathic pain.

Keywords: Ajwain 10%; Aromatic oil; Comfrey root extract; Lavender oil; Nerve pain; Peganum oil; Rose oil; Vitex agnus-castus.

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Conflict of interest statement

The authors declare no conflict of interest.We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

Figures

**Fig. 1**
Mechanistics insight of comfrey root extracts against nerve pain.

See this image and copyright information in PMC

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References

1. National Institute for Health and Care Excellence . NICE Guidel.; 2013. Neuropathic Pain in Adults : Pharmacological Management in Non- Specialist Settings.
1. Murnion B.P. Neuropathic pain: current definition and review of drug treatment. Aust. Prescr. 2018 doi: 10.18773/austprescr.2018.022. - DOI - PMC - PubMed
1. Jensen T.S., et al. A new definition of neuropathic pain. Pain. 2011 doi: 10.1016/j.pain.2011.06.017. - DOI - PubMed
1. Finnerup N.B., et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016 doi: 10.1097/j.pain.0000000000000492. - DOI - PMC - PubMed
1. Dueñas M., Ojeda B., Salazar A., Mico J.A., Failde I. A review of chronic pain impact on patients, their social environment and the health care system. J. Pain Res. 2016 doi: 10.2147/JPR.S105892. - DOI - PMC - PubMed

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[1] National Institute for Health and Care Excellence . NICE Guidel.; 2013. Neuropathic Pain in Adults : Pharmacological Management in Non- Specialist Settings.

[2] National Institute for Health and Care Excellence . NICE Guidel.; 2013. Neuropathic Pain in Adults : Pharmacological Management in Non- Specialist Settings.

[3] Murnion B.P. Neuropathic pain: current definition and review of drug treatment. Aust. Prescr. 2018 doi: 10.18773/austprescr.2018.022. - DOI - PMC - PubMed

[4] Murnion B.P. Neuropathic pain: current definition and review of drug treatment. Aust. Prescr. 2018 doi: 10.18773/austprescr.2018.022. - DOI - PMC - PubMed

[5] Jensen T.S., et al. A new definition of neuropathic pain. Pain. 2011 doi: 10.1016/j.pain.2011.06.017. - DOI - PubMed

[6] Jensen T.S., et al. A new definition of neuropathic pain. Pain. 2011 doi: 10.1016/j.pain.2011.06.017. - DOI - PubMed

[7] Finnerup N.B., et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016 doi: 10.1097/j.pain.0000000000000492. - DOI - PMC - PubMed

[8] Finnerup N.B., et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016 doi: 10.1097/j.pain.0000000000000492. - DOI - PMC - PubMed

[9] Dueñas M., Ojeda B., Salazar A., Mico J.A., Failde I. A review of chronic pain impact on patients, their social environment and the health care system. J. Pain Res. 2016 doi: 10.2147/JPR.S105892. - DOI - PMC - PubMed

[10] Dueñas M., Ojeda B., Salazar A., Mico J.A., Failde I. A review of chronic pain impact on patients, their social environment and the health care system. J. Pain Res. 2016 doi: 10.2147/JPR.S105892. - DOI - PMC - PubMed

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A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights

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A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights

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Abstract

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