Caveat: Monoclonal antibodies 20.1 and 103.2 bind all human BTN3A proteins and are not suited to study BTN3A1-specific features

doi:10.1073/pnas.2304065120

Comment

. 2023 May 16;120(20):e2304065120.

doi: 10.1073/pnas.2304065120. Epub 2023 May 8.

Caveat: Monoclonal antibodies 20.1 and 103.2 bind all human BTN3A proteins and are not suited to study BTN3A1-specific features

Thomas Herrmann¹

Affiliations

PMID: 37155844
PMCID: PMC10193970
DOI: 10.1073/pnas.2304065120

Comment

Caveat: Monoclonal antibodies 20.1 and 103.2 bind all human BTN3A proteins and are not suited to study BTN3A1-specific features

Thomas Herrmann. Proc Natl Acad Sci U S A. 2023.

. 2023 May 16;120(20):e2304065120.

doi: 10.1073/pnas.2304065120. Epub 2023 May 8.

Author

Thomas Herrmann¹

Affiliation

¹ Institute for Virology and Immunobiology, Julius Maximilians Universität Würzburg, 97078 Würzburg, Germany.

PMID: 37155844
PMCID: PMC10193970
DOI: 10.1073/pnas.2304065120

No abstract available

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Conflict of interest statement

The author declares no competing interest.

Comment in

Reply to Herrmann et al.: The BTN3A isoform BTN3A1 is responsible for phosphoantigen-induced Vγ9Vδ2 T cell activation.
Zhou J, Zhang J, Zhang Z, Shen L. Zhou J, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2304723120. doi: 10.1073/pnas.2304723120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155864 Free PMC article. No abstract available.

Comment on

Up-regulation of BTN3A1 on CD14⁺ cells promotes Vγ9Vδ2 T cell activation in psoriasis.
Zhou J, Zhang J, Tao L, Peng K, Zhang Q, Yan K, Luan J, Pan J, Su X, Sun J, Zhang Z, Shen L. Zhou J, et al. Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2117523119. doi: 10.1073/pnas.2117523119. Epub 2022 Oct 26. Proc Natl Acad Sci U S A. 2022. PMID: 36288286 Free PMC article.

Cited by

γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids.
Dong J, Holthaus D, Peters C, Koster S, Ehsani M, Quevedo-Olmos A, Berger H, Zarobkiewicz M, Mangler M, Gurumurthy RK, Hedemann N, Chumduri C, Kabelitz D, Meyer TF. Dong J, et al. Front Immunol. 2023 Nov 27;14:1281646. doi: 10.3389/fimmu.2023.1281646. eCollection 2023. Front Immunol. 2023. PMID: 38090581 Free PMC article.
Reply to Herrmann et al.: The BTN3A isoform BTN3A1 is responsible for phosphoantigen-induced Vγ9Vδ2 T cell activation.
Zhou J, Zhang J, Zhang Z, Shen L. Zhou J, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2304723120. doi: 10.1073/pnas.2304723120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155864 Free PMC article. No abstract available.

References

1. Zhou J., et al. , Up-regulation of BTN3A1 on CD14(+) cells promotes Vgamma9Vdelta2 T cell activation in psoriasis. Proc. Natl. Acad. Sci. U.S.A. 119, e2117523119 (2022). - PMC - PubMed
1. Palakodeti A., et al. , The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)- specific antibodies. J. Biol. Chem. 287, 32780–32790 (2012). - PMC - PubMed
1. Nerdal P. T., et al. , Butyrophilin 3A/CD277-Dependent activation of human gammadelta T cells: Accessory cell capacity of distinct leukocyte populations. J. Immunol. 197, 3059–3068 (2016). - PubMed
1. Harly C., et al. , Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. Blood 120, 2269–2279 (2012). - PMC - PubMed
1. Vantourout P., et al. , Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing gammadelta T cell biology. Proc. Natl. Acad. Sci. U.S.A. 115, 1039–1044 (2018). - PMC - PubMed

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[1] Zhou J., et al. , Up-regulation of BTN3A1 on CD14(+) cells promotes Vgamma9Vdelta2 T cell activation in psoriasis. Proc. Natl. Acad. Sci. U.S.A. 119, e2117523119 (2022). - PMC - PubMed

[2] Zhou J., et al. , Up-regulation of BTN3A1 on CD14(+) cells promotes Vgamma9Vdelta2 T cell activation in psoriasis. Proc. Natl. Acad. Sci. U.S.A. 119, e2117523119 (2022). - PMC - PubMed

[3] Palakodeti A., et al. , The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)- specific antibodies. J. Biol. Chem. 287, 32780–32790 (2012). - PMC - PubMed

[4] Palakodeti A., et al. , The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)- specific antibodies. J. Biol. Chem. 287, 32780–32790 (2012). - PMC - PubMed

[5] Nerdal P. T., et al. , Butyrophilin 3A/CD277-Dependent activation of human gammadelta T cells: Accessory cell capacity of distinct leukocyte populations. J. Immunol. 197, 3059–3068 (2016). - PubMed

[6] Nerdal P. T., et al. , Butyrophilin 3A/CD277-Dependent activation of human gammadelta T cells: Accessory cell capacity of distinct leukocyte populations. J. Immunol. 197, 3059–3068 (2016). - PubMed

[7] Harly C., et al. , Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. Blood 120, 2269–2279 (2012). - PMC - PubMed

[8] Harly C., et al. , Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. Blood 120, 2269–2279 (2012). - PMC - PubMed

[9] Vantourout P., et al. , Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing gammadelta T cell biology. Proc. Natl. Acad. Sci. U.S.A. 115, 1039–1044 (2018). - PMC - PubMed

[10] Vantourout P., et al. , Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing gammadelta T cell biology. Proc. Natl. Acad. Sci. U.S.A. 115, 1039–1044 (2018). - PMC - PubMed

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Caveat: Monoclonal antibodies 20.1 and 103.2 bind all human BTN3A proteins and are not suited to study BTN3A1-specific features

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Caveat: Monoclonal antibodies 20.1 and 103.2 bind all human BTN3A proteins and are not suited to study BTN3A1-specific features

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