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Review
. 2023 May;151(5):1169-1177.
doi: 10.1016/j.jaci.2023.03.013.

Neuroimmune interactions in atopic and allergic contact dermatitis

Andrew W Liu  1 , Jacob E Gillis  1 , Tina L Sumpter  1 , Daniel H Kaplan  2
Affiliations
Review

Neuroimmune interactions in atopic and allergic contact dermatitis

Andrew W Liu et al. J Allergy Clin Immunol. 2023 May.

Abstract

The skin is a barrier organ populated by many types of skin-resident immune cells and sensory neurons. It has become increasingly appreciated that neuroimmune interactions are an important component of inflammatory diseases such as atopic dermatitis and allergic contact dermatitis. Neuropeptides secreted from nerve terminals play an important role in mediating cutaneous immune cell function, and soluble mediators derived from immune cells interact with neurons to induce itch. In this review article, we will explore emerging research describing neuronal effector functions on skin immune cells in mouse models of atopic and contact dermatitis. We will also discuss the contributions of both specific neuronal subsets and secreted immune factors to itch induction and the associated inflammatory processes. Finally, we will explore how treatment strategies have emerged around these findings and discuss the relationship between scratching and dermatitis.

Keywords: Atopic dermatitis; contact dermatitis; itch; neuroimmunology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
Scheme of neuroimmune function in Atopic Dermatitis.
Figure 2.
Figure 2.
Scheme of neuroimmune function in contact hypersensitivity.
See this image and copyright information in PMC

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