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Review
. 2023 Mar 24;15(4):1058.
doi: 10.3390/pharmaceutics15041058.

Phytoconstituent-Loaded Nanofibrous Meshes as Wound Dressings: A Concise Review

Ameya Sharma  1 , Divya Dheer  1   2 , Inderbir Singh  3 , Vivek Puri  1 , Pradeep Kumar  4
Affiliations
Review

Phytoconstituent-Loaded Nanofibrous Meshes as Wound Dressings: A Concise Review

Ameya Sharma et al. Pharmaceutics. .

Abstract

In the past, wounds were treated with natural materials, but modern wound dressings include functional elements to expedite the process of healing and to improve skin recovery. Due to their exceptional properties, nanofibrous wound dressings are now the most cutting-edge and desirable option. Similar in structure to the skin's own extracellular matrix (ECM), these dressings can promote tissue regeneration, wound fluid transportation, and air ductility for cellular proliferation and regeneration owing to their nanostructured fibrous meshes or scaffolds. Many academic search engines and databases, such as Google Scholar, PubMed, and Sciencedirect, were used to conduct a comprehensive evaluation of the literature for the purposes of this investigation. Using the term "nanofibrous meshes" as a keyword, this paper focuses on the importance of phytoconstituents. This review article summarizes the most recent developments and conclusions from studies on bioactive nanofibrous wound dressings infused with medicinal plants. Several wound-healing methods, wound-dressing materials, and wound-healing components derived from medicinal plants were also discussed.

Keywords: nanofibers; phytoconstituents; polysaccharides; wound; wound dressings; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Various stages of the wound-healing mechanism.
Figure 2
Figure 2
Extraction of phytoconstituents from medicinal plants and fabrication of nanofibrous meshes employing electrospinning and its applications.
Figure 3
Figure 3
Electrospun Poly(vinyl alcohol)/Chitosan-g-Poly (N-vinyl imidazole) wound dressing containing titanium dioxide/curcumin showing faster wound healing through better drug release (reprinted with permission [55] from Elsevier).
Figure 4
Figure 4
Different curcumin derivates depicting similar high binding affinity inside transforming growth factor beta type 1 kinase domain (TGF-β) and glycogen synthase kinase-3 beta (GSK3-β) active sites observing their role in wound healing (reprinted with permission [56] from Elsevier).
Figure 5
Figure 5
Representation of new centella total glucoside- and ciprofloxacin-based dual-loaded coaxial nanofiber membrane showing potent wound healing action (reprinted with permission [70] from Elsevier).
Figure 6
Figure 6
Illustration of asiaticoside-loaded coaxially electrospinning nanofibers containing alginate, polyvinyl alcohol (PVA), and chitosan in deep partial-thickness burn injury. (reprinted with permission [71] from Elsevier).
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Grants and funding

This research work is financially supported by the Science and Engineering Research Board (SERB), Department of Science and Technology (DST), India under Teachers Associateship for Research Excellence (TARE) (Grant no. TAR/2022/000526).

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