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Review
. 2023 Oct;25(10):2852-2860.
doi: 10.1007/s12094-023-03167-9. Epub 2023 Apr 24.

Advances in the expression and function of Fyn in different human tumors

Changqing Liu #  1 , Shan Li #  1 , Yunlian Tang  2
Affiliations
Review

Advances in the expression and function of Fyn in different human tumors

Changqing Liu et al. Clin Transl Oncol. 2023 Oct.

Abstract

The tyrosine kinase Fyn is a member of the SRC family of kinases, and its sustained activation is closely linked to tumor cell migration, proliferation, and cell metabolism. Recently, Fyn has been found to be expressed in various tumor tissues, and the expression and function of Fyn vary between tumors, with Fyn acting as an oncogene to promote proliferation and metastasis in some tumors. This article summarizes the recent studies on the role of Fyn in different human tumors, focusing on the role of Fyn in melanoma, breast cancer, glioma, lung cancer, and peripheral T-cell lymphoma in order to provide a basis for future research and targeted therapy in different human tumors.

Keywords: Cancers; Fyn; Gene regulation; Oncogene; SRC.

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