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. 2023 Apr 22;24(1):317.
doi: 10.1186/s12891-023-06417-7.

A comparative study between two methods of delivery of chemotherapeutic agent in patients with bone and soft tissue sarcoma of lower extremity

Jing Shan  1 , Sumei Lv  2 , Haihong Li  3 , Donglai Wang  2 , Xiaoyu Zhang  2 , Wei Liu  2
Affiliations

A comparative study between two methods of delivery of chemotherapeutic agent in patients with bone and soft tissue sarcoma of lower extremity

Jing Shan et al. BMC Musculoskelet Disord. .

Abstract

Background: We aimed to compare the effects of peripherally inserted central catheters (PICC) and implantable venous access devices (TIVADs) in terms of complications and shoulder function in patients with malignant bone and soft tissue tumors of the lower extremities.

Methods: We analyzed 65 cases of TIVADs (chest wall) and 65 cases of PICC at the orthopedic department of the Fourth Hospital of Hebei Medical University between June 2019 and December 2021, which were diagnosed with malignant bone tumors or soft tissue tumors of the lower extremities (tumors had to be relatively sensitive to chemotherapy), received regular chemotherapy, with ≥ 14 cycles (42 weeks). The two groups were compared in terms of catheter indwelling time, catheter-related complications, Constant-Murley shoulder function score, and displacement of the position of the catheter end on the catheterization side.

Results: Compared to the PICC group, at six months after catheterization, the TIVADs group reported better outcomes for catheter indwelling time, catheter-related complications, and Constant-Murley score for the catheterization-side shoulder joint (p < 0.05). The TIVADs group also reported less displacement of the catheter end position after 180° abduction of the catheterization-side shoulder joint (p < 0.05).

Conclusions: Compared with PICC, TIVADs can prolong catheter indwelling time, reduce catheter-related complications, and maintain shoulder joint function, which makes it an ideal venous-access approach when providing chemotherapy to patients with malignant bone and soft tissue tumors of the lower extremities.

Keywords: Catheter complications; Chemotherapy; Shoulder function.

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Conflict of interest statement

We have no conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Position Movement due to Catheterization-Side Shoulder Joint’s 180° Abduction from Neutral Position Note. The movement is marked by a red arrow
Fig. 2
Fig. 2
Port Catheter’s End-Position Movement due to Catheterization-Side Shoulder Joint’s 180° Abduction from Neutral Position (Note. The movement is marked by a red arrow.)
Fig. 3
Fig. 3
Before and After Images of Catheter Relocation for Port Displacement and Folding (Note. The change is marked by a red arrow.)
See this image and copyright information in PMC

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