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Review
. 2023 Mar 27:14:1144980.
doi: 10.3389/fphys.2023.1144980. eCollection 2023.

Role of CD34 in inflammatory bowel disease

Zhiyuan Li  1   2 , Shuyan Dong  1 , Shichen Huang  2 , Yuhan Sun  2 , Yingzhi Sun  1 , Beibei Zhao  2 , Qiulan Qi  1 , Lei Xiong  3 , Feng Hong  4 , Yuxin Jiang  1
Affiliations
Review

Role of CD34 in inflammatory bowel disease

Zhiyuan Li et al. Front Physiol. .

Abstract

Inflammatory bowel disease (IBD) is caused by a variety of pathogenic factors, including chronic recurrent inflammation of the ileum, rectum, and colon. Immune cells and adhesion molecules play an important role in the course of the disease, which is actually an autoimmune disease. During IBD, CD34 is involved in mediating the migration of a variety of immune cells (neutrophils, eosinophils, and mast cells) to the inflammatory site, and its interaction with various adhesion molecules is involved in the occurrence and development of IBD. Although the function of CD34 as a partial cell marker is well known, little is known on its role in IBD. Therefore, this article describes the structure and biological function of CD34, as well as on its potential mechanism in the development of IBD.

Keywords: CD34; adhesion molecules; immune cells; inflammatory bowel disease; integrin; selectin.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Molecular mechanism regulating the rolling and adhesion of immune cells on vascular endothelial cells. CD34-specific glycosylation on the surface of endothelial cells under the stimulation of inflammatory factors recognizes and binds to L-selectin on immune cells. Immune cells driven by the blood flow roll on vascular endothelial cells with the binding force of CD34 and L-selectin. When immune cells are in contact with endothelial cells, CD34 on the surface of the immune cells distributes integrin on their basal region through the negative charge carried by the extracellular region, further improving the contact with endothelial cells to exert the adhesion.
FIGURE 2
FIGURE 2
CD34 is involved in the immune regulation during IBD. When the proportion of harmful bacteria in the intestine increases, many toxic factors and other metabolites are released by harmful bacteria, damaging the intestinal mucosa. Intestinal goblet cells and CD34+ cancer stem cells release inflammatory factors and chemokines that act on vascular endothelial cells, and induce the expression of adhesion factors such as CD34, selectin, and integrin in vascular endothelial cells, increasing the permeability of the vascular wall. Neutrophils are the first reaching the inflammatory site due to the expression of CD34, and then mast cells and eosinophils further roll due to CD34 expressed by vascular endothelial cells and adhere to the inflammatory site by crossing the vascular wall, participating in the inflammatory response.
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Grants and funding

This research was supported by Natural Science Foundation of Anhui Province (1708085QH206), National Natural Science Foundation of China (81671586 and 81270091), Research Start-up Fund Project of Jiaxing University for Introducing Talents (No. CD70519066), and the Municipal Public Welfare Research Project (2022AY10001) from Jiaxing, Zhejiang, China.

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