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Review
. 2023 Mar 30;15(7):2074.
doi: 10.3390/cancers15072074.

Molecular Tailored Therapeutic Options for Advanced Gastrointestinal Stromal Tumors (GISTs): Current Practice and Future Perspectives

Fabio Catalano  1 , Malvina Cremante  1 , Bruna Dalmasso  2 , Chiara Pirrone  1 , Agostina Lagodin D'Amato  1 , Massimiliano Grassi  1 , Danila Comandini  1
Affiliations
Review

Molecular Tailored Therapeutic Options for Advanced Gastrointestinal Stromal Tumors (GISTs): Current Practice and Future Perspectives

Fabio Catalano et al. Cancers (Basel). .

Abstract

Gastrointestinal stromal tumors (GISTs) are one of the most common mesenchymal tumors characterized by different molecular alterations that lead to specific clinical presentations and behaviors. In the last twenty years, thanks to the discovery of these mutations, several new treatment options have emerged. This review provides an extensive overview of GISTs' molecular pathways and their respective tailored therapeutic strategies. Furthermore, current treatment strategies under investigation and future perspectives are analyzed and discussed.

Keywords: advanced GISTs; clinical practice; clinical trials; molecular characterization; precision oncology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
GIST treatment algorithm.
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References

    1. El-Menyar A., Mekkodathil A.A., Al-Thani H. Diagnosis and management of gastrointestinal stromal tumors: An up-to-date literature review. J. Cancer Res. Ther. 2017;13:889–900. - PubMed
    1. Ma G.L., Murphy J.D., Martinez M.E., Sicklick J.K. Epidemiology of Gastrointestinal Stromal Tumors in the Era of Histology Codes: Results of a Population-Based Study. Cancer Epidemiol. Biomark. Prev. 2015;24:298–302. doi: 10.1158/1055-9965.EPI-14-1002. - DOI - PMC - PubMed
    1. Søreide K., Sandvik O.M., Søreide J.A., Giljaca V., Jureckova A., Bulusu V.R. Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies. Cancer Epidemiol. 2016;40:39–46. doi: 10.1016/j.canep.2015.10.031. - DOI - PubMed
    1. Rossi S., Miceli R., Messerini L., Bearzi I., Mazzoleni G., Capella C., Arrigoni G., Sonzogni A., Sidoni A., Toffolatti L., et al. Natural history of imatinib-naive GISTs: A retrospective analysis of 929 cases with long-term follow-up and development of a survival nomogram based on mitotic index and size as continuous variables. Am. J. Surg. Pathol. 2011;35:1646–1656. doi: 10.1097/PAS.0b013e31822d63a7. - DOI - PubMed
    1. Pasini B., McWhinney S.R., Bei T., Matyakhina L., Stergiopoulos S., Muchow M., Boikos S.A., Ferrando B., Pacak K., Assié G., et al. Clinical and molecular genetics of patients with the Carney–Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD. Eur. J. Hum. Genet. 2008;16:79–88. doi: 10.1038/sj.ejhg.5201904. - DOI - PubMed

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