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Review
. 2023 Mar 23:14:1146868.
doi: 10.3389/fendo.2023.1146868. eCollection 2023.

Crosstalk between bone and muscle in chronic kidney disease

Limy Wong  1   2 , Lawrence P McMahon  1   2
Affiliations
Review

Crosstalk between bone and muscle in chronic kidney disease

Limy Wong et al. Front Endocrinol (Lausanne). .

Abstract

With increasing life expectancy, the related disorders of bone loss, metabolic dysregulation and sarcopenia have become major health threats to the elderly. Each of these conditions is prevalent in patients with chronic kidney disease (CKD), particularly in more advanced stages. Our current understanding of the bone-muscle interaction is beyond mechanical coupling, where bone and muscle have been identified as interrelated secretory organs, and regulation of both bone and muscle metabolism occurs through osteokines and myokines via autocrine, paracrine and endocrine systems. This review appraises the current knowledge regarding biochemical crosstalk between bone and muscle, and considers recent progress related to the role of osteokines and myokines in CKD, including modulatory effects of physical exercise and potential therapeutic targets to improve musculoskeletal health in CKD patients.

Keywords: bone; chronic kidney disease; crosstalk; muscle; myokines; osteokines.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Grants and funding

LW is supported by the Royal Australasian College of Physicians Jacquot Establishment Fellowship 2021 (2021REF00021) and 2022 (2022REF00084). The aim of the Jacquot Research Establishment Fellowship is to assist establishment of a career in nephrology research for a nephrologist who has completed a research higher degree in an area of relevance. The Fellowship is supported by the Estate of the late Don and Lorraine Jacquot and co-administered with the Australian and New Zealand Society of Nephrology Fellowship.

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