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Review
. 2023 Jun 15:323:121662.
doi: 10.1016/j.lfs.2023.121662. Epub 2023 Apr 5.

Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis

Mohamed El-Tanani  1 , Hamdi Nsairat  2 , Alaa A Aljabali  3 , Ángel Serrano-Aroca  4 , Vijay Mishra  5 , Yachana Mishra  6 , Gowhar A Naikoo  7 , Walhan Alshaer  8 , Murtaza M Tambuwala  9
Affiliations
Review

Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis

Mohamed El-Tanani et al. Life Sci. .

Abstract

The signalling system known as mammalian target of rapamycin (mTOR) is believed to be required for several biological activities involving cell proliferation. The serine-threonine kinase identified as mTOR recognises PI3K-AKT stress signals. It is well established in the scientific literature that the deregulation of the mTOR pathway plays a crucial role in cancer growth and advancement. This review focuses on the normal functions of mTOR as well as its abnormal roles in cancer development.

Keywords: Apoptosis; Pathological angiogenesis; Rapamycin and rapalogues; Signalling cascade; mTOR.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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