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Review
. 2023 Feb 28;15(3):794.
doi: 10.3390/pharmaceutics15030794.

Modulation of Macrophage Function by Bioactive Wound Dressings with an Emphasis on Extracellular Matrix-Based Scaffolds and Nanofibrous Composites

Tao He  1   2 , Yuzhen Xiao  1 , Zhijun Guo  3 , Yifeng Shi  4 , Qiuwen Tan  2 , Yizhou Huang  1 , Huiqi Xie  1
Affiliations
Review

Modulation of Macrophage Function by Bioactive Wound Dressings with an Emphasis on Extracellular Matrix-Based Scaffolds and Nanofibrous Composites

Tao He et al. Pharmaceutics. .

Abstract

Bioactive wound dressings that are capable of regulating the local wound microenvironment have attracted a very large interest in the field of regenerative medicine. Macrophages have many critical roles in normal wound healing, and the dysfunction of macrophages significantly contributes to impaired or non-healing skin wounds. Regulation of macrophage polarization towards an M2 phenotype provides a feasible strategy to enhance chronic wound healing, mainly by promoting the transition of chronic inflammation to the proliferation phase of wound healing, upregulating the level of anti-inflammatory cytokines around the wound area, and stimulating wound angiogenesis and re-epithelialization. Based on this, modulation of macrophage functions by the rational design of bioactive scaffolds has emerged as a promising way to accelerate delayed wound healing. This review outlines current strategies to regulate the response of macrophages using bioactive materials, with an emphasis on extracellular matrix-based scaffolds and nanofibrous composites.

Keywords: bioactive materials; chronic wounds; extracellular matrix scaffolds; macrophage polarization; nanofibrous composites; wound dressing.

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Conflict of interest statement

The authors declare no conflict of interest.

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