Carcinogenesis Observed in the Spleens of Balb/c Mice After Head-neutron Irradiation
- PMID: 36974803
- DOI: 10.21873/anticanres.16294
Carcinogenesis Observed in the Spleens of Balb/c Mice After Head-neutron Irradiation
Abstract
Background/aim: To investigate the long-term influence of head-neutron irradiation on mice spleens, post-radiation late effects were examined in three types of mice: Balb/c and severe combined immunodeficiency (SCID) mice, which have high radio-sensitivities, and C3H mice.
Materials and methods: Neutron irradiation was performed with the neutron beam of the Kyoto University Research Reactor. Survival fractions and the change in spleen size after head-neutron irradiation were investigated in three different types of mice. Physical condition after neutron irradiation was observed for eighteen months.
Results: The onset of primary splenic malignant lymphoma was recognized in many of the Balb/c mice 18 months after head-neutron irradiation. Eight months after head-neutron irradiation, many SCID mice developed an abscess in the part exposed to radiation and spleen swelling. The swollen spleen of SCID mice had hematopoiesis from the marrow.
Conclusion: Low energy head-neutron irradiation damages immune organs in radiosensitive SCID and Balb/c mice. A combination of boron neutron capture therapy and immunotherapy may be less toxic than low-energy neutron-irradiation alone.
Keywords: BNCT; Neutron; carcinogenesis; malignant lymphoma; spleen.
Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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