Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Mar;49(3):761-6.
doi: 10.1016/S0006-3495(86)83702-X.

Geographical distribution and inactivation kinetics in internally perfused Myxicola giant axons

L Goldman, R E Chandler

Geographical distribution and inactivation kinetics in internally perfused Myxicola giant axons

L Goldman et al. Biophys J. 1986 Mar.

Abstract

In some preparations the time constant of Na current inactivation determined with two pulses (tau c) is larger over some range of potentials than that determined from the current decay during a single pulse (tau h), while in others tau c(V) and tau h(V) are the same. Myxicola giant axons obtained from specimens collected from coastal waters of northeastern North America display a tau c - tau h difference under all conditions we have tested. In these axons tau c(V) and tau h(V) are unchanged by reduction of Na current density, addition of K-channel blockers, or internal perfusion. Specimens of the same species, Myxicola infundibulum, collected from a different geographical location, the south coast of England, have been studied under internal perfusion with K as the major cation internally, with reduced external Na concentration and in the presence of K-channel blockers. In these axons tau c(V) and tau h(V) approximately superpose, raising the possibility that dramatic differences in Na current kinetics may not necessarily reflect basic differences in the organization of the Na channel gating machinery.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Gen Physiol. 1978 Dec;72(6):879-98 - PubMed
    1. Biophys J. 1984 Jan;45(1):51-3 - PubMed
    1. Biophys J. 1975 May;15(5):495-9 - PubMed
    1. J Gen Physiol. 1973 Mar;61(3):361-84 - PubMed
    1. J Membr Biol. 1975 Apr 23;21(1-2):25-47 - PubMed

Publication types

LinkOut - more resources