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Review
. 2023 Mar 2:14:1133020.
doi: 10.3389/fgene.2023.1133020. eCollection 2023.

Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies

Shijin Wang  1 , Bowen Jiang  1 , Deqian Xie  1 , Xiunan Li  1 , Guangzhen Wu  1
Affiliations
Review

Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies

Shijin Wang et al. Front Genet. .

Abstract

Ferroptosis is a new type of cell death characterized by damage to the intracellular microenvironment, which causes the accumulation of lipid hydroperoxide and reactive oxygen species to cause cytotoxicity and regulated cell death. Non-coding RNAs (ncRNAs) play an important role in gene expression at the epigenetic, transcriptional, and post-transcriptional levels through interactions with different DNAs, RNAs, or proteins. Increasing evidence has shown that ferroptosis-related ncRNAs are closely related to the occurrence and progression of several diseases, including urological malignancies. Recently, the role of ferroptosis-associated ncRNAs (long non-coding RNAs, micro RNAs, and circular RNAs) in the occurrence, drug resistance, and prognosis of urological malignancies has attracted widespread attention. However, this has not yet been addressed systematically. In this review, we discuss this issue as much as possible to expand the knowledge and understanding of urological malignancies to provide new ideas for exploring the diagnosis and treatment of urological malignancies in the future. Furthermore, we propose some challenges in the clinical application of ferroptosis-associated ncRNAs.

Keywords: bladder cancer; ferroptosis; kidney cancer; non-coding RNAs; prostate cancer; urological oncology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Regulatory substances and molecular mechanisms of ferroptosis The solute transporter protein SLC7A11 and transmembrane glycoprotein SLC3A2 form the cystine/glutamate transporter system (system XC-), which is embedded on the surface of the cell membrane and mediates the reverse exchange of cystine and glutamate. Cysteine is a key substrate for GSH synthesis. When GSH is depleted, GPX4 activity reduces, and the ROS generated by Fe through the Fenton reaction cannot be reduced, causing lipid peroxidation and oxidative stress, which leads to ferroptosis.
FIGURE 2
FIGURE 2
Ferroptosis-related ncRNAs participate in the regulation of urological malignancies.
See this image and copyright information in PMC

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Grants and funding

GW’s Liaoning Ph.D. Start-up Fund (2021-BS-209, Liaoning, 30,000CNY); GW’s Dalian Young Stars of Science and Technology (2021RQ010, Dalian, 100,000CNY); Liaoning Provincial Education Department (LJKZ0860).

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