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. 2022 Nov-Dec;25(6):1147-1152.
doi: 10.4103/aian.aian_38_22. Epub 2022 Dec 3.

Neuropsychiatric Features, Health-Related Quality of Life, and Caregiver Burden in Parkinson's Disease

Atul Goel  1 , Sunil K Narayan  1 , Ramkumar Sugumaran  1
Affiliations

Neuropsychiatric Features, Health-Related Quality of Life, and Caregiver Burden in Parkinson's Disease

Atul Goel et al. Ann Indian Acad Neurol. 2022 Nov-Dec.

Abstract

Aim: Parkinson's disease (PD) is a progressive neurodegenerative disease and significantly impacts patients and their caregivers. The current study aims at recognizing its neuropsychiatric symptoms, its impact on the health-related quality of life (HRQOL) of the patients, and the caregiver burden in a middle- to-low-income country.

Methods: We conducted a cross-sectional survey of 73 idiopathic Parkinson's disease (IPD) patients and their caregivers from January 2021 to June 2021. Neuropsychiatric Inventory (NPI-12) and Parkinson's disease questionnaire (PDQ-39) were used to assess patients' symptoms and HRQOL, respectively. We used the Zarit caregiver burden interview (ZBI) and Hamilton depression scale (Ham-D) for the caregiver's burden assessment.

Results: Of the 73 patients, 43 (59%) were men, and 30 (41%) were women. Their mean age was 60.25 years (± 11.1), and the mean duration of PD was 6.4 years (± 3.4). Eighty-six percent of the patients reported having one or more neuropsychiatric symptoms. HRQOL, as indicated by PDQ-39, correlated most significantly with H and Y staging (r = 0.680, P < 0.001) of the disease. Sixty-eight percent of the caregivers felt a disease burden, and 55% had depression. On regression analysis, NPI total score on caregiver burden (beta = 0.883, P < 0.001, confidence interval [CI] of 1.087 to 1.400,) and H and Y staging on depression (beta = 0.772, P < 0.001, [CI of 0.629 to 0.934) were having the most decisive impact.

Conclusion: Our study showed the presence of frequent neuropsychiatric symptoms in PD patients. It has a detrimental effect on the quality of life of patients and results in a significant increase in caregiver burden and depression among them.

Keywords: Caregiver burden; Parkinson's disease; movement disorders; neuropsychiatric symptoms; quality of life.

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Conflict of interest statement

There are no conflicts of interest.

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