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. 2023 Jan 17;11(2):201.
doi: 10.3390/vaccines11020201.

Mathematical Modeling and Analysis of the Dynamics of RNA Viruses in Presence of Immunity and Treatment: A Case Study of SARS-CoV-2

Khalid Hattaf  1   2 , Mly Ismail El Karimi  2 , Ahmed A Mohsen  3   4 , Zakaria Hajhouji  2 , Majda El Younoussi  2 , Noura Yousfi  2
Affiliations

Mathematical Modeling and Analysis of the Dynamics of RNA Viruses in Presence of Immunity and Treatment: A Case Study of SARS-CoV-2

Khalid Hattaf et al. Vaccines (Basel). .

Abstract

The emergence of novel RNA viruses like SARS-CoV-2 poses a greater threat to human health. Thus, the main objective of this article is to develop a new mathematical model with a view to better understand the evolutionary behavior of such viruses inside the human body and to determine control strategies to deal with this type of threat. The developed model takes into account two modes of transmission and both classes of infected cells that are latently infected cells and actively infected cells that produce virus particles. The cure of infected cells in latent period as well as the lytic and non-lytic immune response are considered into the model. We first show that the developed model is well-posed from the biological point of view by proving the non-negativity and boundedness of model's solutions. Our analytical results show that the dynamical behavior of the model is fully determined by two threshold parameters one for viral infection and the other for humoral immunity. The effect of antiviral treatment is also investigated. Furthermore, numerical simulations are presented in order to illustrate our analytical results.

Keywords: RNA viruses; SARS-CoV-2; antiviral treatment; immunity; mathematical modeling.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The flowchart representing the dynamics of model (1).
Figure 2
Figure 2
The relationship between R0 and several parameters.
Figure 3
Figure 3
Sensitivity indices diagram for R0.
Figure 4
Figure 4
Dynamical behavior of model (1) when R0=0.9030<1.
Figure 5
Figure 5
Dynamical behavior of model (1) when R0=2.6009>1 and R1W=0.9910<1.
Figure 6
Figure 6
Dynamical behavior of model (1) when R0=2.6009>1 and E2=(3.2263×104,18.0990,36.2015,75.0259,8.6286).
Figure 7
Figure 7
Impact of treatment on the dynamics of SARS-CoV-2 infection.
See this image and copyright information in PMC

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