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. 2023 Feb 24;23(1):51.
doi: 10.1186/s12876-023-02684-9.

The role of high serum triglyceride levels on pancreatic necrosis development and related complications

Nils Jimmy Hidalgo  1   2 , Elizabeth Pando  3   4 , Piero Alberti  2 , Rodrigo Mata  2 , Nair Fernandes  2 , Montse Adell  2 , Sara Villasante  2 , Laia Blanco  2 , Joaquim Balsells  2 , Ramon Charco  2
Affiliations

The role of high serum triglyceride levels on pancreatic necrosis development and related complications

Nils Jimmy Hidalgo et al. BMC Gastroenterol. .

Abstract

Background: The relevance of elevated serum triglyceride (TG) levels in the early stages of acute pancreatitis (AP) not induced by hypertriglyceridemia (HTG) remains unclear. Our study aims to determine the role of elevated serum TG levels at admission in developing pancreatic necrosis.

Methods: We analyzed the clinical data collected prospectively from patients with AP. According to TG levels measured in the first 24 h after admission, we stratified patients into four groups: Normal TG (< 150 mg/dL), Borderline-high TG (150-199 mg/dL), High TG (200-499 mg/dL) and Very high TG (≥ 500 mg/dL). We analyzed the association of TG levels and other risk factors with the development of pancreatic necrosis.

Results: A total of 211 patients were included. In the Normal TG group: 122, in Borderline-high TG group: 38, in High TG group: 44, and in Very high TG group: 7. Pancreatic necrosis developed in 29.5% of the patients in the Normal TG group, 26.3% in the Borderline-high TG group, 52.3% in the High TG group, and 85.7% in the Very high TG group. The trend analysis observed a significant association between higher TG levels and pancreatic necrosis (p = 0.001). A multivariable analysis using logistic regression showed that elevated TG levels ≥ 200 mg/dL (High TG and Very high TG groups) were independently associated with pancreatic necrosis (OR: 3.27, 95% CI - 6.27, p < 0.001).

Conclusions: An elevated TG level at admission ≥ 200 mg/dl is independently associated with the development of pancreatic necrosis. The incidence of pancreatic necrosis increases proportionally with the severity of HTG.

Keywords: Acute pancreatitis; Hypertriglyceridemia; Pancreatic necrosis; Triglyceride.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Patient enrollment according to inclusion and exclusion criteria. AP: acute pancreatitis, TG: triglyceride, HTG: hypertriglyceridemia
Fig. 2
Fig. 2
The proportion of pancreatic necrosis for the categories of TG levels in patients with acute pancreatitis. Cochran-Armitage test for trend was significant (p = 0.001). TG: triglyceride
See this image and copyright information in PMC

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References

    1. Fagenholz PJ, Castillo CF, Harris NS, Pelletier AJ, Camargo CA. Increasing United States hospital admissions for acute pancreatitis, 1988–2003. Ann Epidemiol. 2007;17:491–497. doi: 10.1016/j.annepidem.2007.02.002. - DOI - PubMed
    1. Wang S, Li S, Feng Q, Feng X, Xu L, Zhao Q. Overweight is an additional prognostic factor in acute pancreatitis: a meta-analysis. Pancreatology. 2011;11:92–98. doi: 10.1159/000327688. - DOI - PubMed
    1. Bradley EL. A clinically based classification system for acute pancreatitis summary of the international symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch Surg. 1993;128:586–590. doi: 10.1001/archsurg.1993.01420170122019. - DOI - PubMed
    1. Singh VK, Bollen TL, Wu BU, Repas K, Maurer R, Yu S, et al. An assessment of the severity of interstitial pancreatitis. Clin Gastroenterol Hepatol. 2011;9:1098–1103. doi: 10.1016/j.cgh.2011.08.026. - DOI - PubMed
    1. Banks PA, Freeman ML. Practice Parameters Committee of the American College of Gastroenterology. Practice guidelines in acute pancreatitis. Am J Gastroenterol. 2006;101:2379–2400. doi: 10.1111/j.1572-0241.2006.00856.x. - DOI - PubMed