The Impact of COVID-19 Infection on Miscellaneous Inflammatory Disorders of the Gastrointestinal Tract

doi:10.1016/j.gtc.2022.10.002

Review

. 2023 Mar;52(1):115-138.

doi: 10.1016/j.gtc.2022.10.002. Epub 2022 Oct 7.

The Impact of COVID-19 Infection on Miscellaneous Inflammatory Disorders of the Gastrointestinal Tract

Mitchell S Cappell¹, Martin Tobi², David M Friedel³

Affiliations

¹ Division of Gastroenterology, Department of Medicine, Aleda E. Lutz Veterans Hospital, Gastroenterology Service, Main Building, Room 3212, 1500 Weiss Street, Saginaw, MI 48602, USA. Electronic address: mitchell.cappell@va.gov.
² Department of Research and Development, John D. Dingell Veterans Affairs Medical Center, 4747 John R. Street, Detroit, MI 48201, USA.
³ Division of Therapeutic Endoscopy, Division of Gastroenterology, Department of Medicine, NY of New York University Langone Hospital, 259 1st Street, Mineola, NY 11501, USA.

PMID: 36813420
PMCID: PMC9537253
DOI: 10.1016/j.gtc.2022.10.002

Review

The Impact of COVID-19 Infection on Miscellaneous Inflammatory Disorders of the Gastrointestinal Tract

Mitchell S Cappell et al. Gastroenterol Clin North Am. 2023 Mar.

. 2023 Mar;52(1):115-138.

doi: 10.1016/j.gtc.2022.10.002. Epub 2022 Oct 7.

Authors

Mitchell S Cappell¹, Martin Tobi², David M Friedel³

Affiliations

¹ Division of Gastroenterology, Department of Medicine, Aleda E. Lutz Veterans Hospital, Gastroenterology Service, Main Building, Room 3212, 1500 Weiss Street, Saginaw, MI 48602, USA. Electronic address: mitchell.cappell@va.gov.
² Department of Research and Development, John D. Dingell Veterans Affairs Medical Center, 4747 John R. Street, Detroit, MI 48201, USA.
³ Division of Therapeutic Endoscopy, Division of Gastroenterology, Department of Medicine, NY of New York University Langone Hospital, 259 1st Street, Mineola, NY 11501, USA.

PMID: 36813420
PMCID: PMC9537253
DOI: 10.1016/j.gtc.2022.10.002

Abstract

The novel coronavirus pandemic of COVID-19 has emerged as a highly significant recent threat to global health with about 600,000,000 known infections and more than 6,450,000 deaths worldwide since its emergence in late 2019. COVID-19 symptoms are predominantly respiratory, with mortality largely related to pulmonary manifestations, but the virus also potentially infects all parts of the gastrointestinal tract with related symptoms and manifestations that affect patient treatment and outcome. COVID-19 can directly infect the gastrointestinal tract because of the presence of widespread angiotensin-converting enzyme 2 receptors in the stomach and small intestine that can cause local COVID-19 infection and associated inflammation. This work reviews the pathopysiology, clinical manifestations, workup, and treatment of miscellaneous inflammatory disorders of the gastrointestinal tract other than inflammatory bowel disease.

Keywords: COVID-19; Gastrointestinal; Inflammation; Pandemic; SARS.

Published by Elsevier Inc.

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Cited by

In the SARS-CoV-2 Pandora Pandemic: Can the Stance of Premorbid Intestinal Innate Immune System as Measured by Fecal Adnab-9 Binding of p87:Blood Ferritin, Yielding the FERAD Ratio, Predict COVID-19 Susceptibility and Survival in a Prospective Population Database?
Tobi M, Bluth MH, Rossi NF, Demian E, Talwar H, Tobi YY, Sochacki P, Levi E, Lawson M, McVicker B. Tobi M, et al. Int J Mol Sci. 2023 Apr 19;24(8):7536. doi: 10.3390/ijms24087536. Int J Mol Sci. 2023. PMID: 37108697 Free PMC article.

References

1. Schreiber M. What a million Covid dead means for the U.S.’s future. Scientific Am. Available at: www.scientificamerican.com March 29 2022. Accessed April 8, 2022.
1. Parohan M., Yaghoubi S., Seraji A., et al. Risk factors for mortality in patients with coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies. Aging Male. 2020;23(5):1416–1424. - PubMed
1. Daniell H., Nair S.K., Esmaeili N., et al. Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection. Mol Ther. 2022;30(5):1966–1978. - PMC - PubMed
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[1] Schreiber M. What a million Covid dead means for the U.S.’s future. Scientific Am. Available at: www.scientificamerican.com March 29 2022. Accessed April 8, 2022.

[2] Schreiber M. What a million Covid dead means for the U.S.’s future. Scientific Am. Available at: www.scientificamerican.com March 29 2022. Accessed April 8, 2022.

[3] Parohan M., Yaghoubi S., Seraji A., et al. Risk factors for mortality in patients with coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies. Aging Male. 2020;23(5):1416–1424. - PubMed

[4] Parohan M., Yaghoubi S., Seraji A., et al. Risk factors for mortality in patients with coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies. Aging Male. 2020;23(5):1416–1424. - PubMed

[5] Daniell H., Nair S.K., Esmaeili N., et al. Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection. Mol Ther. 2022;30(5):1966–1978. - PMC - PubMed

[6] Daniell H., Nair S.K., Esmaeili N., et al. Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection. Mol Ther. 2022;30(5):1966–1978. - PMC - PubMed

[7] de Sousa F.A.C.G., Paradella T.C. Considerations on oral manifestations of COVID-19. J Med Virol. 2021;93(2):667–668. - PMC - PubMed

[8] de Sousa F.A.C.G., Paradella T.C. Considerations on oral manifestations of COVID-19. J Med Virol. 2021;93(2):667–668. - PMC - PubMed

[9] Barbato L., Bernardelli F., Braga G., et al. Surface disinfection and protective masks for SARS-CoV-2 and other respiratory viruses: A review by SIdP COVID-19 task force. Oral Dis. 2020;18:10. - PMC - PubMed

[10] Barbato L., Bernardelli F., Braga G., et al. Surface disinfection and protective masks for SARS-CoV-2 and other respiratory viruses: A review by SIdP COVID-19 task force. Oral Dis. 2020;18:10. - PMC - PubMed

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The Impact of COVID-19 Infection on Miscellaneous Inflammatory Disorders of the Gastrointestinal Tract

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The Impact of COVID-19 Infection on Miscellaneous Inflammatory Disorders of the Gastrointestinal Tract

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