The Impact of COVID-19 Infection on Miscellaneous Inflammatory Disorders of the Gastrointestinal Tract
- PMID: 36813420
- PMCID: PMC9537253
- DOI: 10.1016/j.gtc.2022.10.002
The Impact of COVID-19 Infection on Miscellaneous Inflammatory Disorders of the Gastrointestinal Tract
Abstract
The novel coronavirus pandemic of COVID-19 has emerged as a highly significant recent threat to global health with about 600,000,000 known infections and more than 6,450,000 deaths worldwide since its emergence in late 2019. COVID-19 symptoms are predominantly respiratory, with mortality largely related to pulmonary manifestations, but the virus also potentially infects all parts of the gastrointestinal tract with related symptoms and manifestations that affect patient treatment and outcome. COVID-19 can directly infect the gastrointestinal tract because of the presence of widespread angiotensin-converting enzyme 2 receptors in the stomach and small intestine that can cause local COVID-19 infection and associated inflammation. This work reviews the pathopysiology, clinical manifestations, workup, and treatment of miscellaneous inflammatory disorders of the gastrointestinal tract other than inflammatory bowel disease.
Keywords: COVID-19; Gastrointestinal; Inflammation; Pandemic; SARS.
Published by Elsevier Inc.
Similar articles
-
Effects of coronavirus disease 19 on the gastrointestinal tract and the potential impact on gastrointestinal toxicities during cancer treatment.Curr Opin Support Palliat Care. 2022 Sep 1;16(3):168-173. doi: 10.1097/SPC.0000000000000604. Curr Opin Support Palliat Care. 2022. PMID: 35929563 Review.
-
Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses.mBio. 2020 Dec 11;11(6):e03185-20. doi: 10.1128/mBio.03185-20. mBio. 2020. PMID: 33310781 Free PMC article.
-
Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases: A dangerous liaison?World J Gastroenterol. 2021 May 21;27(19):2270-2280. doi: 10.3748/wjg.v27.i19.2270. World J Gastroenterol. 2021. PMID: 34040321 Free PMC article. Review.
-
COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract.World J Gastroenterol. 2020 Aug 21;26(31):4579-4588. doi: 10.3748/wjg.v26.i31.4579. World J Gastroenterol. 2020. PMID: 32884218 Free PMC article. Review.
-
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms.Signal Transduct Target Ther. 2020 Nov 2;5(1):256. doi: 10.1038/s41392-020-00373-7. Signal Transduct Target Ther. 2020. PMID: 33139693 Free PMC article. Review.
Cited by
-
In the SARS-CoV-2 Pandora Pandemic: Can the Stance of Premorbid Intestinal Innate Immune System as Measured by Fecal Adnab-9 Binding of p87:Blood Ferritin, Yielding the FERAD Ratio, Predict COVID-19 Susceptibility and Survival in a Prospective Population Database?Int J Mol Sci. 2023 Apr 19;24(8):7536. doi: 10.3390/ijms24087536. Int J Mol Sci. 2023. PMID: 37108697 Free PMC article.
References
-
- Schreiber M. What a million Covid dead means for the U.S.’s future. Scientific Am. Available at: www.scientificamerican.com March 29 2022. Accessed April 8, 2022.
-
- Parohan M., Yaghoubi S., Seraji A., et al. Risk factors for mortality in patients with coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies. Aging Male. 2020;23(5):1416–1424. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous