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. 2022 Nov 10;12(4):341-346.
doi: 10.4103/jmss.JMSS_66_20. eCollection 2022 Oct-Dec.

Drug Repurposing Against Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Through Computational Approach

Golnaz Vaseghi  1 , Ali Golestaneh  2 , Leila Jafari  3 , Fahimeh Ghasemi  4
Affiliations

Drug Repurposing Against Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Through Computational Approach

Golnaz Vaseghi et al. J Med Signals Sens. .

Abstract

Ongoing novel coronavirus (COVID-19) with high mortality is an infectious disease in the world which epidemic in 2019 with human-human transmission. According to the literature, S-protein is one of the main proteins of COVID-19 that bind to the human cell receptor angiotensin-converting enzyme 2 (ACE2). In this study, it was attempted to identify the main effective drugs approved that may be repurposed to the binding site of ACE2. High throughput virtual screening based on the docking study was performed to know which one of the small-molecules had a potential interaction with ACE2 structure. Forasmuch as investigating and identifying the best ACE2 inhibitors among more than 3,500 small-molecules is time-consuming, supercomputer was utilized to apply docking-based virtual screening. Outputs of the proposed computational model revealed that vincristine, vinbelastin and bisoctrizole can significantly bind to ACE2 and may interface with its normal activity.

Keywords: Angiotensin-converting enzyme 2; computer simulation; coronavirus disease 19; drug repurposing; high-throughput virtual screening.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic of the proposed model
Figure 2
Figure 2
ACE2 in complex with (a) Indinavir, (b) Retapamulin, (c) Saquinavir
See this image and copyright information in PMC

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