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Comment
. 2023 Feb 1;8(1):50.
doi: 10.1038/s41392-023-01334-6.

The fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses

Zhi Zong  1   2 , Fangfang Zhou  3 , Long Zhang  4   5   6
Affiliations
Comment

The fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses

Zhi Zong et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Cancer-associated fungi found in different body sites and gene expression signatures. Fungi found to promote tumorigenesis in different body sites (lung, breast, skin, brain, bone, ovary, colon, head-and-neck, stomach) are listed. Fungi that were highly enriched in cancers and may serve as potential prognostic markers are highlighted in red. The presence of Candida in head-and-neck and colon tumors appears to be associated with pro-tumorigenic and cellular adhesion-related gene pathways, whereas in stomach tumors it seems to be involved in inflammatory responses that ultimately lead to poor prognosis. Multiple fungal-bacterial-immune ecologies were detected across tumors. These mycotypes may be promising to predict the survival of patients with cancer
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Comment on

  • Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions.
    Narunsky-Haziza L, Sepich-Poore GD, Livyatan I, Asraf O, Martino C, Nejman D, Gavert N, Stajich JE, Amit G, González A, Wandro S, Perry G, Ariel R, Meltser A, Shaffer JP, Zhu Q, Balint-Lahat N, Barshack I, Dadiani M, Gal-Yam EN, Patel SP, Bashan A, Swafford AD, Pilpel Y, Knight R, Straussman R. Narunsky-Haziza L, et al. Cell. 2022 Sep 29;185(20):3789-3806.e17. doi: 10.1016/j.cell.2022.09.005. Cell. 2022. PMID: 36179670 Free PMC article.

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