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Review
. 2022 Dec 20;15(1):10.
doi: 10.3390/pharmaceutics15010010.

The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions

Javier Salazar  1   2   3 , Thais Carmona  1   3   4   5 , Flavia C Zacconi  2   6   7 , Diego Venegas-Yazigi  3   5 , Claudio Cabello-Verrugio  3   8   9 , Won Il Choi  10 , Cristian Vilos  1   3   7
Affiliations
Review

The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions

Javier Salazar et al. Pharmaceutics. .

Abstract

Skin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body's internal organs. Dermis represents the main section of the skin, and its contribution to skin physiology is critical due to its diverse cellularity, vasculature, and release of molecular mediators involved in the extracellular matrix maintenance and modulation of the immune response. Skin structure and complexity limit the transport of substances, promoting the study of different types of nanoparticles that penetrate the skin layers under different mechanisms intended for skin illness treatments and dermo-cosmetic applications. In this work, we present a detailed morphological description of the dermis in terms of its structures and resident cells. Furthermore, we analyze the role of the dermis in regulating skin homeostasis and its alterations in pathophysiological conditions, highlighting its potential as a therapeutic target. Additionally, we describe the use of nanoparticles for skin illness treatments focused on dermis release and promote the use of metal-organic frameworks (MOFs) as an integrative strategy for skin treatments.

Keywords: dermis; drug delivery; metal-organic frameworks (MOFs); nanoparticles; skin.

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Conflict of interest statement

The authors declare no conflict of interest. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Figures

Figure 1
Figure 1
Illustration of skin components and their cell distribution.
Figure 2
Figure 2
Scheme of potential skin penetration routes of different types of nanoparticles.
Figure 3
Figure 3
Morphological structure of MIL100 metal-organic frameworks (MOFs) acquired by electronic transmission microscopy (TEM), and some schematic representations of MOFs applications on the skin.
See this image and copyright information in PMC

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