COVID-19 and New-Onset Psychosis: A Comprehensive Review

doi:10.3390/jpm13010104

Review

. 2023 Jan 2;13(1):104.

doi: 10.3390/jpm13010104.

COVID-19 and New-Onset Psychosis: A Comprehensive Review

Lorenzo Moccia^{1

2}, Georgios D Kotzalidis^{1

3}, Giovanni Bartolucci², Sara Ruggiero², Laura Monti¹, Marco Biscosi², Beatrice Terenzi², Ottavia M Ferrara², Marianna Mazza^{1

2}, Marco Di Nicola^{1

2}, Delfina Janiri^{1

2}, Alessio Simonetti^{1

2}, Emanuele Caroppo⁴, Luigi Janiri^{1

2}, Gabriele Sani^{1

2}

Affiliations

¹ Department of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, L.go Agostino Gemelli 8, 00168 Rome, Italy.
² Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
³ Department of Neurosciences, Mental Health, and Sensory Organs (NESMOS), Sapienza University of Rome, Sant'Andrea Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy.
⁴ Department of Mental Health, Local Health Authority ROMA 2, 00159 Rome, Italy.

PMID: 36675765
PMCID: PMC9865730
DOI: 10.3390/jpm13010104

Review

COVID-19 and New-Onset Psychosis: A Comprehensive Review

Lorenzo Moccia et al. J Pers Med. 2023.

. 2023 Jan 2;13(1):104.

doi: 10.3390/jpm13010104.

Authors

Affiliations

¹ Department of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, L.go Agostino Gemelli 8, 00168 Rome, Italy.
² Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
³ Department of Neurosciences, Mental Health, and Sensory Organs (NESMOS), Sapienza University of Rome, Sant'Andrea Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy.
⁴ Department of Mental Health, Local Health Authority ROMA 2, 00159 Rome, Italy.

PMID: 36675765
PMCID: PMC9865730
DOI: 10.3390/jpm13010104

Abstract

Psychosis is a multifactorial condition that typically involves delusions, hallucinations, and disorganized thought, speech or behavior. The observation of an association between infectious epidemics and acute psychosis dates back to the last century. Recently, concerns have been expressed regarding COVID-19 and the risk for the development of new-onset psychosis. This article reviewed the current evidence of a possible link between SARS-CoV-2 and risk of psychosis as an acute or post-infectious manifestation of COVID-19. We here discuss potential neurobiological and environmental factors as well as a number of challenges in ascribing a causal pathogenic relationship between SARS-CoV-2 infection and new-onset psychosis.

Keywords: bipolar disorder; delirium; inflammation; schizophrenia; side effects; viral infection.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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1. Mazza M., Caroppo E., De Berardis D., Marano G., Avallone C., Kotzalidis G.D., Janiri D., Moccia L., Simonetti A., Conte E., et al. Psychosis in Women: Time for Personalized Treatment. J. Pers. Med. 2021;11:1279. doi: 10.3390/jpm11121279. - DOI - PMC - PubMed
1. Moccia L., Janiri D., Pepe M., Dattoli L., Molinaro M., De Martin V., Chieffo D., Janiri L., Fiorillo A., Sani G., et al. Affective temperament, attachment style, and the psychological impact of the COVID-19 outbreak: An early report on the Italian general population. Brain Behav. Immun. 2020;87:75–79. doi: 10.1016/j.bbi.2020.04.048. - DOI - PMC - PubMed
1. Klaser K., Thompson E.J., Nguyen L.H., Sudre C.H., Antonelli M., Murray B., Canas L.S., Molteni E., Graham M.S., Kerfoot E., et al. Anxiety and depression symptoms after COVID-19 infection: Results from the COVID Symptom Study app. J. Neurol. Neurosurg. Psychiatry. 2021;92:1254–1258. doi: 10.1136/jnnp-2021-327565. - DOI - PMC - PubMed

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[1] Radua J., Ramella-Cravaro V., Ioannidis J.P.A., Reichenberg A., Phiphopthatsanee N., Amir T., Yenn Thoo H., Oliver D., Davies C., Morgan C., et al. What causes psychosis? An umbrella review of risk and protective factors. World Psychiatry. 2018;17:49–66. doi: 10.1002/wps.20490. - DOI - PMC - PubMed

[2] Radua J., Ramella-Cravaro V., Ioannidis J.P.A., Reichenberg A., Phiphopthatsanee N., Amir T., Yenn Thoo H., Oliver D., Davies C., Morgan C., et al. What causes psychosis? An umbrella review of risk and protective factors. World Psychiatry. 2018;17:49–66. doi: 10.1002/wps.20490. - DOI - PMC - PubMed

[3] Arciniegas D.B. Psychosis. Behav. Neurol. Neuropsychiatry. 2015;21:715–736. doi: 10.1212/01.CON.0000466662.89908.e7. - DOI - PMC - PubMed

[4] Arciniegas D.B. Psychosis. Behav. Neurol. Neuropsychiatry. 2015;21:715–736. doi: 10.1212/01.CON.0000466662.89908.e7. - DOI - PMC - PubMed

[5] Mazza M., Caroppo E., De Berardis D., Marano G., Avallone C., Kotzalidis G.D., Janiri D., Moccia L., Simonetti A., Conte E., et al. Psychosis in Women: Time for Personalized Treatment. J. Pers. Med. 2021;11:1279. doi: 10.3390/jpm11121279. - DOI - PMC - PubMed

[6] Mazza M., Caroppo E., De Berardis D., Marano G., Avallone C., Kotzalidis G.D., Janiri D., Moccia L., Simonetti A., Conte E., et al. Psychosis in Women: Time for Personalized Treatment. J. Pers. Med. 2021;11:1279. doi: 10.3390/jpm11121279. - DOI - PMC - PubMed

[7] Moccia L., Janiri D., Pepe M., Dattoli L., Molinaro M., De Martin V., Chieffo D., Janiri L., Fiorillo A., Sani G., et al. Affective temperament, attachment style, and the psychological impact of the COVID-19 outbreak: An early report on the Italian general population. Brain Behav. Immun. 2020;87:75–79. doi: 10.1016/j.bbi.2020.04.048. - DOI - PMC - PubMed

[8] Moccia L., Janiri D., Pepe M., Dattoli L., Molinaro M., De Martin V., Chieffo D., Janiri L., Fiorillo A., Sani G., et al. Affective temperament, attachment style, and the psychological impact of the COVID-19 outbreak: An early report on the Italian general population. Brain Behav. Immun. 2020;87:75–79. doi: 10.1016/j.bbi.2020.04.048. - DOI - PMC - PubMed

[9] Klaser K., Thompson E.J., Nguyen L.H., Sudre C.H., Antonelli M., Murray B., Canas L.S., Molteni E., Graham M.S., Kerfoot E., et al. Anxiety and depression symptoms after COVID-19 infection: Results from the COVID Symptom Study app. J. Neurol. Neurosurg. Psychiatry. 2021;92:1254–1258. doi: 10.1136/jnnp-2021-327565. - DOI - PMC - PubMed

[10] Klaser K., Thompson E.J., Nguyen L.H., Sudre C.H., Antonelli M., Murray B., Canas L.S., Molteni E., Graham M.S., Kerfoot E., et al. Anxiety and depression symptoms after COVID-19 infection: Results from the COVID Symptom Study app. J. Neurol. Neurosurg. Psychiatry. 2021;92:1254–1258. doi: 10.1136/jnnp-2021-327565. - DOI - PMC - PubMed

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COVID-19 and New-Onset Psychosis: A Comprehensive Review

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COVID-19 and New-Onset Psychosis: A Comprehensive Review

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