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Review
. 2022 Nov 25;51(5):634-639.
doi: 10.3724/zdxbyxb-2022-0224.

Platelet derived growth factor and its receptor in intracerebral hemorrhage

Baojie Mao  1   2 , Ming Wang  2 , Shu Wan  2
Affiliations
Review

Platelet derived growth factor and its receptor in intracerebral hemorrhage

Baojie Mao et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. .

Abstract

Intracerebral hemorrhage (ICH) is a common and highly disabling or fatal neurological disorder in adults. Recent studies have suggested that the platelet derived growth factor (PDGF) signaling pathway plays an important role in the development of ICH. PDGF is involved in vascular remodeling and can be used as a biomarker of cerebral amyloid angiopathy which is one of the major causes of ICH. PDGF and its receptors are involved in the mechanism of the secondary injury after ICH by affecting the integrity of the blood-brain barrier and inflammatory response. PDGF and its receptors may also participate in the mechanism of repair after ICH by promoting angiogenesis. This article reviews the latest research progress on the involvement of PDGF signaling pathway in the pathophysiology of intracerebral hemorrhage, and introduces the relevant antagonists using PDGFR as the therapeutic target, to provide information for the development of therapeutic options for intracerebral hemorrhage.

Keywords: Blood-brain barrier; Inflammation; Intracerebral hemorrhage; Platelet derived growth factor; Platelet derived growth factor receptor; Review.

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Conflict of interest statement

所有作者均声明不存在利益冲突

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Grants and funding

浙江省自然科学基金（Y21H090041）；浙江省重点研发项目（2021C03105）；浙江省医药卫生科技计划（WKJ-ZJ-2014）