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Review
. 2022 Dec 15;27(24):8919.
doi: 10.3390/molecules27248919.

Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?

Domenica Francesca Mariniello  1   2 , Valentino Allocca  1   2 , Vito D'Agnano  1   2 , Riccardo Villaro  3 , Luigi Lanata  4 , Michela Bagnasco  4 , Luigi Aronne  1   2 , Andrea Bianco  1   2 , Fabio Perrotta  1   2
Affiliations
Review

Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?

Domenica Francesca Mariniello et al. Molecules. .

Abstract

COVID-19 is an infective disease resulting in widespread respiratory and non-respiratory symptoms prompted by SARS-CoV-2 infection. Interaction between SARS-CoV-2 and host cell receptors prompts activation of pro-inflammatory pathways which are involved in epithelial and endothelial damage mechanisms even after viral clearance. Since inflammation has been recognized as a critical step in COVID-19, anti-inflammatory therapies, including both steroids and non-steroids as well as cytokine inhibitors, have been proposed. Early treatment of COVID-19 has the potential to affect the clinical course of the disease regardless of underlying comorbid conditions. Non-steroidal anti-inflammatory drugs (NSAIDs), which are widely used for symptomatic relief of upper airway infections, became the mainstay of early phase treatment of COVID-19. In this review, we discuss the current evidence for using NSAIDs in early phases of SARS-CoV-2 infection with focus on ketoprofen lysine salt based on its pharmacodynamic and pharmacokinetic features.

Keywords: COVID-19; NSAIDs; SARS-CoV-2; inflammation; ketoprofen.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Proposed mechanisms of action of Ketoprofen lysine salt in SARS-CoV-2 infection. ROS: reactive oxygen species.
See this image and copyright information in PMC

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