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. 2022 Nov 9:84:104844.
doi: 10.1016/j.amsu.2022.104844. eCollection 2022 Dec.

Types of T-cell lymphoma-a cytogenetic perspective

Muhammad Ammar Samad  1 , Eman Mahboob  1 , Aimen Shafiq  1 , Mohammad Hassam Ur Rehman  1 , Ayesha Sheikh  1 , Zoaib Habib Tharwani  1
Affiliations

Types of T-cell lymphoma-a cytogenetic perspective

Muhammad Ammar Samad et al. Ann Med Surg (Lond). .

Abstract

T cell lymphoma, a type of non-Hodgkin lymphomas is a rare form of malignancy with poor outcomes. TCLS are a heterogeneous group of lymphoid malignancies that occur in nodal and extranodal sites. There are two main types of TCLs namely T-lymphoblastic lymphoma/leukemia and Peripheral T-cell lymphomas classified based on clinical manifestations and cytogenetic mutations. The use of advance technology like karyotyping, fluorescent in situ hybridization (FISH), comparative genomic hybridization (CGH) has allowed us to study TCLs in detail and to observe a different biochemical change that occurs in different TCLs allowing us to classify and treat them differently. This review focuses on the different mutations occurring in different TCLs and how they help us distinguish one type from another.

Keywords: Cytogenetics; Mutations; Non-hodgkin lymphomas; T-cell lymphomas.

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Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Genetic abnormalities in Angioimmunoblastic T-cell lymphoma (AITL), Anaplastic Large cell Lymphoma (ALCL) and Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS). From “Genomics of Peripheral T-Cell Lymphoma and Its Implications for Personalized Medicine” by Zhang Y 2020, Frontiers in oncology, 10, 898. https://doi.org/10.3389/fonc.2020.00898.
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