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Review
. 2024;64(16):5242-5268.
doi: 10.1080/10408398.2022.2153355. Epub 2022 Dec 9.

Dietary restriction in senolysis and prevention and treatment of disease

Sepideh Aminzadeh-Gohari  1   2   3 , Barbara Kofler  1 , Chiara Herzog  2   3
Affiliations
Review

Dietary restriction in senolysis and prevention and treatment of disease

Sepideh Aminzadeh-Gohari et al. Crit Rev Food Sci Nutr. 2024.

Abstract

Aging represents a key risk factor for a plethora of diseases. Targeting detrimental processes which occur during aging, especially before onset of age-related disease, could provide drastic improvements in healthspan. There is increasing evidence that dietary restriction (DR), including caloric restriction, fasting, or fasting-mimicking diets, extend both lifespan and healthspan. This has sparked interest in the use of dietary regimens as a non-pharmacological means to slow aging and prevent disease. Here, we review the current evidence on the molecular mechanisms underlying DR-induced health improvements, including removal of senescent cells, metabolic reprogramming, and epigenetic rejuvenation.

Keywords: aging; dietary restriction; disease prevention; epigenetics; senescence; senolysis; senolytics.

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

Figures

Figure 1.
Figure 1.
Schematic overview of involvement of senescent cells in aging and how DR may aid disease prevention or treatment and increase healthspan. Abbreviations: SASP, senescence-associated secretory phenotype; DNAme: DNA methylation; ROS: reactive oxygen species.
See this image and copyright information in PMC

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